Transoesophageal Echocardiography in Liver Transplantation

End Stage Liver Disease Clinical Trial

Official title:

Transoesophageal Echocardiography in Liver Transplantation: Left Ventricular Function During Reperfusion

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00547924
• Other study ID #: StV 11-2006
• Status: Completed
• Phase: N/A
• First received: October 22, 2007
• Last updated: April 9, 2014
• Start date: April 2006
• Est. completion date: January 2010

Study information

• Verified date: April 2014
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Swissmedic
• Study type: Observational

Clinical Trial Summary

Severe hypotension during reperfusion in liver transplantation is a frequent adverse event. Rare data exist so far about pathophysiology of this phenomenon. The exact role of left ventricular function, which might be impaired causing hypotension, has not been elucidated during the period of reperfusion.

Goal of this study is to:

• perform transesophageal echocardiography in order to assess systolic and diastolic left ventricular function during reperfusion

• determine inflammatory mediators in the plasma which could cause left ventricular dysfunction

Recruitment information / eligibility

• Status: Completed
• Enrollment: 17
• Est. completion date: January 2010
• Est. primary completion date: January 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 75 Years

Eligibility

Inclusion criteria:

• Patients on waiting list for liver transplantation.

• Age: 18-75 years.

Exclusion criteria:

• Strictures, tumours and diverticula of the oesophagus.

• History of oesophageal varices with recent bleeding.

• Oesophageal varices and prothrombin time less than 20% or platetlets les than 30000/ml.

• Instable cervical spine.

• Involvement in other studies.

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

• End Stage Liver Disease
• Liver Diseases

Intervention

Behavioral:
• Transoesophageal echocardiography
Transoesophageal echocardiography in liver transplantation: left ventricular function during reperfusion

Locations

Country	Name	City	State
Switzerland	University Hospital Zurich, Institute for Anesthesiology	Zurich

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland,