End Stage Kidney Disease Clinical Trial
Official title:
Clinical Study Investigating the Performance and Compatibility Characteristics of the Baxter Hollow Fiber Dialyzer Xenium XPH 210 During On-line Hemodiafiltration
The proposed study seeks to determine the appropriate balance between the removal of undesirable small molecular substances (urea, creatinine, phosphate) and large molecular substances (ß2-m) and the retention of important substances (e.g.albumin) for the Baxter Xenium XPH dialyzer type under defined therapeutic conditions of olHDF primarily concerning filtration flow rates in relation to blood flow/plasma water flow rates. Furthermore the possibility of the removal of certain protein-bound substances shall be investigated together with the impact of increasing ultrafiltration on the parameters of the micro-inflammation.
The new high flux dialyser membrane Xenium XPH 210 from Baxter will show an considerably
increased removal of ß2-Microglobulin with olHDF in post dilution mode together with a
markedly increased removal of small molecules (urea, creatinine, phosphate). The loss of
albumin will depend on the treatment modalities. However, the albumin permeability is
tolerable over the whole range of total filtration rate selected and applied to the
patients.
Together with the albumin loss into the filtrate/dialysate a small amount of albuminbound
substances is detectable.
Parameters of micro-inflammation can be influenced by an increasing convective part of the
treatment.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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