Encephalitis Clinical Trial
Official title:
Core Cerebrospinal Fluid Biomarker Profile in Leucine Rich Glioma Inactivated 1 (LGI1) Antibody Associated Encephalitis
Limbic encephalitis associated with anti leucine-rich glioma inactivated-1 LGI1 antibody
(anti-LGI1) usually presents with seizures and progressive disturbance of memory and
behavior. But anti-LGI1 associated encephalitis (LGI1-E) could present with a variety of
features including an elective cognitive form of the disease, which mimicks a
neurodegenerative condition such as Creutzfeld Jakob disease or rapidly progressive Alzheimer
disease. In these patients, the appropriate diagnosis could be challenging.
The primary aim of this study is to describe cerebrospinal fluid biomarkers in a cohort of
LGI1-E patients as results of these markers are currently not described in LGI1-E. Moreover,
patients with LGI1-E often present seizures. At this point, the impact on cerebrospinal fluid
biomarkers has not been described in this condition. The secondary aims of this study are to
compare cerebrospinal fluid (CSF) biomarkers in LGI1-E patients to these in other
neurodegenerative conditions ( e.g. creutzfeld Jakob disease, Alzheimer disease), which are
considered as a possible differential diagnosis in these patients. The last aim of this study
is to look for correlations between cerebrospinal fluid biomarkers in LGI1-E and clinical
data in these patients, especially seizure.
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