Medical Treatment of Early-Enamel Carious Lesion Using Different Remeneralizing Agents

Enamel Caries Clinical Trial

Official title: Medical Treatment of Early-Enamel Carious Lesion Using Different Remeneralizing Agents: 2-years Randomized Clinical Trial

Status Completed

Clinical Trial Summary

Medical Treatment of Early-Enamel Carious Lesion using Different Remeneralizing agents

Clinical Trial Description

Medical management of incipient lesions by application of remineralizing agents like fluoride therapy, amorphous calcium phosphate (ACP), and Casin phosphopeptide amorphous calcium phosphate (CPP-ACP) has proved to be effective in reversing such lesions. Fluoride was considered the "gold standard" remineralizing agent , However several recent researchers found that; the ideal remineralizing agents should diffuse or deliver calcium and phosphate ions into early enamel lesion. Calcium-silicate based material such as β-CaSiO3 and β-Ca2SiO4 play an important role in hard tissue regeneration, showing good bioactivity and biocompatibility and can induce bone like apetite formation in stimulated body fluids. when β-CaSiO3 and β-Ca2SiO4 come in contact with saliva it will be dissolve forming silanol group (Si-O ) on the enamel surface which can bind to Ca ions and inducing the precipitation of hydroxyapatite. In the light of this, this study was designed to compare the remineralization potential of silver diamine flouride/ potassium iodide, casin phosphopeptide amorphous calcium phosphate and experimental tricalcium silicate on early enamel lesions. ;

Related Conditions & MeSH terms

• Dental Caries
• Enamel Caries

• NCT number: NCT05296213
• Study type: Interventional
• Source: Mansoura University
• Status: Completed
• Phase: N/A
• Start date: December 1, 2019
• Completion date: January 10, 2022