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Clinical Trial Summary

Medical Treatment of Early-Enamel Carious Lesion using Different Remeneralizing agents


Clinical Trial Description

Medical management of incipient lesions by application of remineralizing agents like fluoride therapy, amorphous calcium phosphate (ACP), and Casin phosphopeptide amorphous calcium phosphate (CPP-ACP) has proved to be effective in reversing such lesions. Fluoride was considered the "gold standard" remineralizing agent , However several recent researchers found that; the ideal remineralizing agents should diffuse or deliver calcium and phosphate ions into early enamel lesion. Calcium-silicate based material such as β-CaSiO3 and β-Ca2SiO4 play an important role in hard tissue regeneration, showing good bioactivity and biocompatibility and can induce bone like apetite formation in stimulated body fluids. when β-CaSiO3 and β-Ca2SiO4 come in contact with saliva it will be dissolve forming silanol group (Si-O ) on the enamel surface which can bind to Ca ions and inducing the precipitation of hydroxyapatite. In the light of this, this study was designed to compare the remineralization potential of silver diamine flouride/ potassium iodide, casin phosphopeptide amorphous calcium phosphate and experimental tricalcium silicate on early enamel lesions. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05296213
Study type Interventional
Source Mansoura University
Contact
Status Completed
Phase N/A
Start date December 1, 2019
Completion date January 10, 2022

See also
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Completed NCT04685889 - Resin Infiltration Treatment for MIH N/A
Not yet recruiting NCT06425536 - Efficacy of Remineralizing Products Used in Molar Grooves: Evaluation With Diagnodent Pen and Diagnocam N/A
Completed NCT04756557 - Caries-preventing Effect of a Hydroxyapatite-toothpaste in Adults N/A
Not yet recruiting NCT03774498 - Effect of Different Over-the-counter Toothpastes on Enamel Remineralization N/A