Emergence Agitation Clinical Trial
The occurrence of emergence agitation (EA) in pediatric patients who have received
sevoflurane anesthesia is a common postoperative problem. The prevalence of EA varies
between 10% to 80% depending on the scoring system for evaluation and the anesthetic
technique used.
Many authors reported various strategies such as use of sedative premedication, change of
maintenance technique of anesthesia, or pharmacological agents administered at the end of
anesthesia to reduce the incidence and severity of EA, and to allow a smooth emergence from
sevoflurane anesthesia. Among these strategies, the use of pharmacological agents at the end
of anesthesia is not affected by anesthetic duration, and may not prolong recovery duration
of anesthesia excessively when these agents are administered as subhypnotic or small dose.
The typical agents that can be administered in this way are propofol and fentanyl.
Previous studies demonstrated that the use of either propofol or fentanyl at the end of
anesthesia could reduce the incidence of EA.
The purpose of this study is to compare the preventive effect on EA and the characteristics
of anesthesia recovery between propofol and fentanyl administered at the end of sevoflurane
anesthesia.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Investigator)
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
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Risk Factors for Pediatric Emergence Agitation and Analysis of Serum or Urine Metabonomics in Children With Agitation
|
||
| Completed |
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The Effect of Depth of Anesthesia as Measured by Bispectral Index (BIS) on Emergence Agitation in Children
|
N/A | |
| Not yet recruiting |
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Effect of Dexmedetomidine on Emergence Agitation and Postoperative Behavior Changes in Children
|
Early Phase 1 | |
| Active, not recruiting |
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Caudal Versus Intravenous Magnesium Sulfate on Emergence Agitation After Sevoflurane In Children.
|
N/A | |
| Completed |
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Emergence Agitation and Pain Scores in Pediatrics When Comparing Single-modal vs Multi-modal Analgesia for ENT Surgery
|
Early Phase 1 | |
| Completed |
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The Effect of Low Flow Anesthesia on Postoperative Emergence Agitation in Rhinoplasty
|
N/A | |
| Completed |
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Can Acetaminophen Given 1-2 Hours to Children Before Ear Tube Surgery Reduce Agitation After Anesthesia?
|
Phase 4 | |
| Not yet recruiting |
NCT05624424 -
Effect of Rematazolam Besylate, Propofol, and Sevoflurane Perioperative Sedation on Incidence of Emergence Agitation and Hemodynamics in Patients Undergoing Laparoscopic Abdominal Surgery
|
Phase 4 | |
| Completed |
NCT04168879 -
Sphenopalatine Ganglion Block for Nasal Surery
|
N/A | |
| Not yet recruiting |
NCT06079710 -
Effect of Intraoperative and Awakening Electroencephalogram on Awakening Agitation After General Anesthesia in Children
|
||
| Recruiting |
NCT04142840 -
Dexmedetomidine and Propofol in the Treatment of Emergence Agitation
|
Early Phase 1 | |
| Completed |
NCT04844333 -
Effect of Extubation Under Deep Anesthesia on Emergence Agitation of Nasal Surgery
|
N/A | |
| Recruiting |
NCT02169843 -
Small Doses of Dexmedetomidine for Emergence Agitation
|
Phase 4 | |
| Completed |
NCT04820595 -
Postoperative Neurocognitive Dysfunction: Is There Any Place for Emergency Agitation: A Prospective Cohort Trial
|
||
| Not yet recruiting |
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Propofol Versus Dexmedetomidine Effect on Prevention Emergence Agitation
|
Phase 4 | |
| Recruiting |
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|
N/A | |
| Completed |
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A Comparison of Emergence Agitation by Sevoflurane for Intraoperative Sedation Associated With Caudal Block
|
N/A | |
| Completed |
NCT03807011 -
Emergence Agitation in Pediatric Strabismus Surgery
|
N/A | |
| Completed |
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Effect of Dexmedetomedine in Subtenon's Block on Emergence Agitation in Pediatric Strabismus Surgery
|
N/A | |
| Completed |
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Transition to Propofol After Sevoflurane Anaesthesia to Prevent Emergence Agitation
|
Phase 4 |