Clinical Trials Logo

Clinical Trial Summary

The embryologist will oad the embryos into the catheter at the right position, then the catheter will be slowly pushed through the cervical canal, 1-2 cm beneath the fundus 5.5 cm away from the cervical external os.The embryos will be delivered by pushing the plunger of the syringe from the mid-cavitary positioned catheter and keeping the plunger pushed down.

Study Group: The catheter will be pulled back slowly and without rotation with the plunger still pushed forward.

Control Group: The catheter will be pulled back slowly with a 360°rotation with the plunger kept pushed forward.


Clinical Trial Description

Patients to be included will be those meeting the study criteria who present at Istanbul Zeynep Kamil Training and Research Hospital, In vitro fertilization unit between February 1, 2017 and August, 2017.

The voluntary participants of the study will undergo controlled ovarian stimulation that is routinely performed in our clinic, followed by ovum pick up (OPU) and embryo transfer procedure. Volunteers will be asked to hold the urine 2 hours before the procedure to ensure fullness of the bladder. Identification details will be checked to verify that the names on the embryo containers are correct. The embryos will be examined by the embryologist. The participants will be informed before the procedure about the fertilization rates, number and quality of the developed embryos, the number of embryos to be transferred and the number of embryos planned to be frozen. Patients will undergo the procedure in the lithotomy position.The fullness of the bladder will be verified by inserting a speculum cervix and the vagina will be cleaned with a sterile serum physiological saline solution (SF) sponge, and cervical mucus aspired from the external os gently with a special soft aspirator catheter.

After the cervix is cleaned with culture liquid, a trial transfer will be performed with a sterile catheter. At this stage, only the soft internal catheter will pass through the internal os and the outer sheath will be stopped when it reaches the internal os. The outer sheath of the catheter will be advanced 2 cm into the cervical canal under ultrasound guidance and will be stopped before passing the internal os. Once it is ensured that the soft catheter is inside the endometrial cavity, the embryologist will be informed of the appropriate catheter position. Embryologist will oad the embryos into the catheter at the right position, then the catheter will be slowly pushed through the cervical canal, 1-2 cm beneath the fundus 5.5 cm away from the cervical external os. The embryos will be delivered by pushing the plunger of the syringe from the mid-cavitary positioned catheter and keeping the plunger pushed down. Afterwards, the volunteers will be randomly divided into two groups. Randomization will be ensured by a computer-based programme.

- 1st Group Volunteers: The catheter will be pulled back slowly and without rotation with the plunger still pushed forward.

- 2nd GroupVolunteers:The catheter will be pulled back slowly with a 360° rotation with the plunger kept pushed forward. The speculum will remain in the cervix until the embryologist checks the catheter for the presence of any embryos, blood or mucus.

Parameters to be Reviewed: Age, weight, height of the participants, primary/secondary infertility, infertility duration, presence of additional diseases, gravida, parity, abortion history, endometrial thickness on the day of HCG, infertility reasons, baseline and total gonadotropin dose, stimulation period, number of collected oocytes, number of M2 oocytes, quality of transferred embryos, BhCG positivity ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03097042
Study type Interventional
Source Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Contact
Status Completed
Phase N/A
Start date February 1, 2017
Completion date August 31, 2017

See also
  Status Clinical Trial Phase
Recruiting NCT05737381 - Quality of Human Embryos in IVF, Culturing in Differentiated Oxygen N/A
Enrolling by invitation NCT02313311 - Select Embryos by Time-lapse System for Single Embryo Transfer N/A
Recruiting NCT04795440 - Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF N/A
Completed NCT02971878 - Comparisons of Human Embryonic Development Using Single Medium With and Without the Addition of Antioxidants N/A
Completed NCT03354013 - Genetic Screening and Assisted Oocyte Activation in Couples With Diminished/Aberrant Embryonic Development. N/A
Not yet recruiting NCT03810040 - Effect of Degranulation Needle With Different Diameters on the Rate Good Embryo in IVF N/A
Completed NCT02999958 - Adding Antioxidants Into Human Sequential Culture Media System N/A