Embryo Development Clinical Trial
Official title:
The Clinical Outcome of Ultra-low Oxygen Tension on Post Thawed Human Blastocyst
The clinical outcome of Ultra-low oxygen tension on post thawed human blastocyst
In vitro, Embryo development depends on several factors as temperature, pH, and oxygen in the
surrounding environment of the embryo. Impaired culture conditions are highly correlated with
poor embryo development. Oxygen is a powerful regulator of embryo function , as it is
responsible for cell respiration, energy production and rapid cell growth . Increased levels
of oxygen is associated with an increase in the levels of ROS , which leads to unfavorable
culture conditions, as it might affect the stability of cell membrane, DNA, and protein
function .
In the female reproductive tract, oxygen concentration fluctuates between 2-8%, which is
considered to be at its highest level in the fallopian tube, while the lowest level is in the
uterus . Pre-implantation embryo crosses the uterotubal junction after the time of compaction
on Day 3, where it is exposed to a shift in oxygen tension to 2%. This variation may have a
role in the metabolic reactions of the embryo, and in its preparation for implantation
process.
Some studies suggested that culturing embryos with oxygen tension below 5% may have an
embryological advantage mimicking nature.
Embryological laboratories routinely use low Oxygen tension (5%). Our purpose is to
investigate if ultra-low oxygen tension (2%) has an advantage over low oxygen tension (5%)
for post thawed human embryo regarding clinical outcomes.
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