Embolism, Pulmonary Clinical Trial
Official title:
Clinical Echography in Emergency Prognostic Evaluation of Pulmonary Embolism: ECU -EP Study.
Pulmonary Embolism (PE) is a frequent disease, the third cause of cardiovascular death after
stroke and myocardial infarction. According to European guidelines of European Society of
Cardiology (ESC) and of European Respiratory Society (ERS), the prognostic stratification of
PE severity is mandatory as soon as PE is diagnosed. This stratification includes the
hemodynamic status, and specific tools : the assessment of the sPESI score, and the
evaluation of PE's impact on right ventricle (RV) : increased biomarkers (troponin, BNP) and
right ventricle/left ventricle (RV/LV) ratio.
the RV/LV ration may be evaluated ideally by transthoracic echo (TTE), or by CT scan.
Unfortunately, only 10% of patients with PE are evaluated with TTE by a cardiologist in the
initial time of PE diagnosis. Hence, the CT scan is the most frequent way to assess RV/LV
ratio. However, CT is not possible for all patients (patients with contra-indication) or may
have difficulties to provide a clear assessment because of technical issues.
Then, there is a need for morphological evaluation of RV as soon as PE is diagnosed, in every
clinical setting. The improvement in technologies allowed the development of clinical
echography (CE) in emergency departments.
CE is already available, non-invasive, less expansive, and may be a good way to assess RV/LV
ratio in patients with PE diagnosed in emergency departments.
The investigators propose a prospective, multicenter study to assess the sensitivity of CE in
patients with PE, compared to CT scan to detect RV/LV ≥0.9.
n/a
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