Electroretinography Clinical Trial
Official title:
Electroretinographic Changes in Healthy Young Men Before and After Induction of Glucose Intolerance by Glucocorticoids Treatment, Hyperphagia and Lack of Exercise
The purpose is to investigate the electroretinogram (ERG) in young, healthy men in the normoglycaemic and hyperglycaemic state before and after intervention with corticosteroids treatment, high calorie diet and exercise restraint.
The subjects will be fasting from midnight the day before the experiment. Standard
procedures (including pupil dilation, dark adaptation, and local anaesthetics) are carried
out to allow the ERG to be obtained. After electrophysiology, the subject will be clamped at
a plasma glucose level of 10 mM (~180 mg/dL) and after a stabilisation period the ERG
protocol is repeated.
Each subject is examined twice on two different days. The first day the subjects are
normoglycaemic in the morning (first examination) and hyperglycaemic (clamped to 10 mM)
throughout the second examination. The second day subjects are also normoglycaemic and
hyperglycaemic but shows up after 7-12 days of daily intake of prednisolone, high calorie
diet, and exercise restraint.
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Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science