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Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC — SWITCHED  

Electronic Cigarette Use Clinical Trial

Official title:
Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC

Clinical Trial Summary

The goal of this study is to conduct a pilot randomized waitlist-controlled trial to assess the feasibility, acceptability, and preliminary effects of substituting the NIDA standardized research e-cigarette (SREC) for combusted cigarettes in MOUD-TUD who are not ready to quit smoking. A waitlist controlled RCT using a mixed-methods sequential explanatory design will investigate the impact of SREC provision on: 1) tobacco use behavior (e.g., cigarettes per day [primary outcome], SREC use), 2) biomarkers (e.g., carbon monoxide, anabasine), 3) cigarette dependence and withdrawal, and 4) short-term health effects and tolerability (e.g., respiratory symptoms, substance use). In the proposed RCT, N=40 adults stable on MOUD with buprenorphine who report daily smoking recruited from MGH primary care practices will be randomly assigned to receive the SREC for 8 weeks, either immediately (iSREC), or after an 8-week delay (waitlist control [WLC]). They will be followed an additional 4 weeks after SREC provision ends (to 12 weeks in iSREC and 20 weeks in WLC).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05881304
Study type Interventional
Source Massachusetts General Hospital
Contact Joanna M Streck, PhD
Phone 617-643-9977
Email jstreck@mgh.harvard.edu
Status Not yet recruiting
Phase N/A
Start date July 1, 2024
Completion date June 1, 2026
View Details
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