Clinical Trials Logo

Clinical Trial Summary

Purpose: Assessing nociception and sedation in mechanically ventilated patients in the ICU is challenging, with few reliable methods available for continuous monitoring. Measurable cardiovascular and neurophysiological variables, such as blood pressure, heart rate, frontal EEG, and frontal EMG, might provide a medium for sedation and nociception monitoring. The hypothesis of this explorative study is that the aforementioned variables correlate with the level of sedation, as described by the Richmond Agitation-Sedation score (RASS).

Methods: Thirty adult postoperative ICU patients on mechanical ventilation and receiving intravenous sedation, excluding patients with primary neurological disorders, head injury, or need for continuous neuromuscular blockage. Continuous measurements of bispectral index (BIS), EMG power (EMG), EMG-derived Responsiveness Index (RI), averaged blood pressure variability (ARV), and Surgical Pleth Index (SPI) were tested against repeated RASS measurements, and separately against responsiveness to painful stimuli at varying RASS levels.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04472247
Study type Observational
Source University of Helsinki
Contact
Status Completed
Phase
Start date May 7, 2007
Completion date April 1, 2009

See also
  Status Clinical Trial Phase
Recruiting NCT05114551 - ICU Predictive Score of WEaning Success in Patients At Risk of Extubation Failure
Completed NCT05547646 - The Prevalence of Healthcare-associated Infection in Medical Intensive Care Units in Tunisia
Recruiting NCT03697785 - Weaning Algorithm for Mechanical VEntilation N/A
Completed NCT02922101 - Evaluation of the Effectiveness of an Audit and Feedback Intervention With Quality Improvement Toolbox in Intensive Care N/A
Completed NCT02902783 - DONATE-Pilot Study on ICU Management of Deceased Organ Donors
Completed NCT01857986 - Evaluating Air Leak Detection in Intubated Patients N/A
Completed NCT01885442 - TryCYCLE: A Pilot Study of Early In-bed Leg Cycle Ergometry in Mechanically Ventilated Patients N/A
Recruiting NCT03810768 - Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness
Completed NCT03295630 - Validity of an Actigraph Accelerometer Following Critical Illness N/A
Not yet recruiting NCT05518955 - VR Integrated Into Multicomponent Interventions for Improving Sleep in ICU N/A
Recruiting NCT05556811 - HEaling LIght Algorithms for the ICU Patient N/A
Recruiting NCT05702411 - Air Stacking Technique For Pulmonary Reexpansion N/A
Completed NCT02741453 - Bilateral Internal Jugular Veins Ultrasound Scanning Prior to CVC Placement N/A
Recruiting NCT04979897 - Impact on Mental, Physical, And Cognitive Functioning of a Critical Care sTay During the COVID-19 Pandemic
Completed NCT05281224 - Ventilator Tube Holder for Patients With a Tracheostomy
Withdrawn NCT02970903 - VitalPAD: an Intelligent Monitoring and Communication Device to Optimize Safety in the PICU N/A
Recruiting NCT02587273 - The Pharmacokinetics of Fentanyl in Intensive Care Patients Phase 4
Completed NCT02661607 - Point of Care Echocardiography Versus Chest Radiography for the Assessment of Central Venous Catheter Placement N/A
Completed NCT01479153 - Venous Site for Central Catheterization N/A
Recruiting NCT06110390 - High-flow Nasal Oxygen Therapy to Prevent Extubation Failure in Adult Trauma Intensive Care Patients N/A