Major Depression Clinical Trial
Official title:
The Effects of Sevoflurane or Ketamine on QTc Interval During Electroconvulsive Therapy
The aim of this study was to evaluate the effect of sevoflurane or ketamine on the QTc and Tp-e interval during in patients with major depression.
Patients enrolled in the study are randomly allocated by computer-generated random numbers
to receive either sevoflurane or ketamine for their initial ECT session. They subsequently
receive an alternative study drug in their next session, continuing to alternate between
drugs at each session until the sixth session. In group S, sevoflurane are initiated at %8
sevoflurane for anesthesia induction and maintained at 2% to %4 until the electrical
stimulus is delivered, In group K, ketamine are given to 1mg/kg ıv bolus.
Electrical stimulus is delivered via bilateral frontotemporal electrodes.The mean arterial
pressure (MAP), HR, and ECG are recorded before anesthetic induction (T1), after anesthetic
induction (T2) and at 0, 1, 3, 10 min after the seizure ended (T3, T4, T5 and T6,
respectively).The QT interval and Tp-e interval are measured by one author, who was unaware
of group allocation.
;
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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