| Eligibility |
Inclusion Criteria:
- Be able to verbalize understanding of consent form and able to provide written
informed consent;
- Healthy male or female: No known history of a clinically significant medical diagnosis
in the opinion of the Investigator and is not receiving prescription medication except
birth control therapies; this includes but is not limited to no history of heart or
lung disease (including latent tuberculosis), high blood pressure, history of any
cardiac or endocrine disease (including thyroid disease and diabetes); appendectomy
and cholecystectomy are allowed;
- Aged =18 and =60 years at the time of screening;
- Body mass index =18.0 and =30.0 kg/m^2, and body weight of =50 kg, at screening and
Day -2;
- Non- or ex-smoker; an ex-smoker is defined as someone who completely stopped using
nicotine products for at least 180 days prior to the first study drug administration;
- A female participant meeting 1 of the following criteria: (1) female participants of
child-bearing potential using adequate contraception during and for at least 90 days
after any administration of study medication; or (2) physiological postmenopausal
status, defined as the following: absence of menses for at least 1 year prior to the
first study drug administration (not due to amenorrhea secondary to lactation); and
follicle stimulating hormone (FSH) levels =40 mIU/mL at screening; or (3) surgical
postmenopausal status, defined as the following: bilateral oophorectomy; and absence
of menses for at least 90 days prior to the first study drug administration; and FSH
levels =40 mIU/mL at screening; or (4) surgical sterilization including tubal
ligation, salpingectomy and hysterectomy. If the postmenopausal participant has an FSH
of <40 mIU/mL, but meets the above criteria in either (1), (2), (3) or (4) (for all
aspects other than FSH levels) as well as all the other inclusion criteria, the
participant may be included in the study if the estradiol serum level measured at
screening is equal to or below 150 pmol/L. If male, non-vasectomized participants with
female partners of child-bearing potential must agree to use contraception and agree
not to donate sperm during the study period and for 90 days after the last study drug
administration;
- Willing to communicate with an investigator and site staff and comply with all study
procedures and requirements.
Exclusion Criteria:
- An uninterpretable or abnormal screening electrocardiogram (ECG) indicating a second-
or third-degree atrioventricular block, or one or more of the following: QRS interval
>110 msec; QTcF >450 msec; PR interval >200 msec; HR <40 bpm; or any rhythm other than
sinus rhythm that is interpreted an investigator to be clinically significant;
- History of risk factors for torsades de pointes, including unexplained syncope, known
long QT syndrome, heart failure, myocardial infarction, angina, or clinically
significant abnormal laboratory assessments including hypokalemia, hypercalcemia, or
hypomagnesemia. Participants will also be excluded if there is a family history of
long QT syndrome or Brugada syndrome;
- A sustained supine systolic blood pressure >150 mm Hg or <90 mm Hg or a supine
diastolic blood pressure >95 mm Hg or <50 mm Hg at screening or on Day -1. Blood
pressure may be retested more than once in the supine position. The blood pressure
abnormality is considered sustained if either the systolic or the diastolic pressure
values are outside the stated limits after 3 assessments and the participant may not
be randomized;
- A resting HR of <40 bpm or >100 bpm when vital signs are measured at screening or on
Day -1;
- Unstable cardiovascular disease, including recent myocardial infarction or cardiac
arrhythmia;
- History of acquired immunodeficiency syndrome or positive test results for human
immunodeficiency virus, hepatitis C virus antibody, or hepatitis B surface antigen at
screening;
- Positive urine drug or alcohol screen at screening or on Day -2 (admission);
- Clinically significant illness, including viral syndromes within 3 weeks prior to Day
1;
- Women who are pregnant according to a serum pregnancy test (or planning to become
pregnant within the next 6 months) or currently breastfeeding, at screening or
according to a urine pregnancy test on Day -2 (admission);
- Participation in another investigational drug or device study or treated with an
investigational drug within 30 days or 5 half-lives, whichever is longer, prior to Day
1;
- Received avacopan previously;
- Consumed more than 21 units of ethanol per week at any time in the 6 months prior to
Day 1 (1 unit of ethanol is equivalent to 8 ounces of beer, 4 ounces of wine, or 1
ounce of spirits) or history of alcoholism and/or drug/chemical abuse within 5 years;
- Use of prescription medications (with the exception of hormone replacement therapy and
hormonal birth control), including nonsteroidal anti-inflammatory drugs or sucralfate
and medications known to prolong the QT/QTc interval or herbal preparations within 14
days or 5 half-lives (whichever is longer) prior to Day 1, or use of an
over-the-counter medication, vitamins, or supplements (including omega-3 fish oils)
within 7 days prior to Day 1;
- Use of alcohol-, caffeine-, or xanthine-containing products, Seville oranges (sour),
grapefruit, or grapefruit juice, within 72 hours prior to Day 1;
- Strenuous activity (e.g., sports) from 96 hours (4 days) prior to entry into the
clinical research unit (on Day -2) and throughout the study (until the final follow-up
visit is conducted);
- Donated more than 500 mL of blood or significant blood loss within 60 days prior to
signing the informed consent form;
- Any other medical, psychological, or social condition that, in the opinion of an
investigator, would prevent the participant from fully participating in the study,
would represent a concern for study compliance, or would constitute a safety concern
to the participant;
- An employee of an investigator or study center with direct involvement in the proposed
study or other studies under the direction of that investigator or study center, as
well as a family member of the employee or investigator;
- Known hypersensitivity to drugs including moxifloxacin;
- Participants taking strong CYP3A4 inducers (e.g., phenytoin, fosphenytoin, rifampicin,
carbamazepine, St. John's Wort, nevirapine, pentobarbital, primidone, rifapentine,
enzalutamide, lumacaftor, mitotane, apalutamide, quinine, rimexolone, rifaximin,
rifamycin, topiramate, oxcarbazepine) or moderate CYP3A4 inducers (e.g., bosentan,
efavirenz, etravirine, modafinil, dexamethasone, etravirine, nafcillin, dabrafenib,
methotrexate, bexarotene, mifepristone) within 2 weeks prior to prior to Day 1;
- Positive screening tuberculosis blood test.
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