Elective Non-cardiac Surgery Clinical Trial
Official title:
Assoziationen Von Leukozyten-Sub-Populationen im Blut kardiovaskulärer Risikopatienten Mit Der Inzidenz Perioperativer kardiovaskulärer Ereignisse
The potential use of regulatory T cells as preoperative risk stratification tool is evaluated in order to improve clinical risk stratification and reduce perioperative morbidity and mortality.
Annually, there are more than 200 million surgeries worldwide. The POISE study revealed 5% of
patients undergoing a non-cardiac surgery suffer perioperative myocardial infarcts going
along with a perioperative mortality rate of about 11,6%. Possibilities to preoperatively
identify patients at risk are limited and prophylactic interventions are not yet established
or controversial.
Selected leukocyte subpopulations have been demonstrated to be associated with higher risk
for cardiovascular events.
The aim of this study is to evaluate the potential use of regulatory T cells as preoperative
risk stratification tool in order to improve clinical risk stratification and reduce
perioperative morbidity and mortality. Therefore, high-risk cardiovascular patients scheduled
for major non-cardiac surgery will be recruited. Blood will be drawn at predefined time
points before surgery and up to three days postoperatively. Leukocytes will be analyzed by
flow cytometry. During 30 day follow up adverse cardiovascular events will be recorded. ECGs
will be recorded preoperatively and on post-OP day 3. High-sensitive cardiac Troponin T will
be measured prior to the operation and on post-OP day one to three. The patient chart will be
screened for cardiovascular events up to day 30. A telephone interview will be performed to
detect cardiovascular events after discharge until post-OP day 30.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02874508 -
Leukocytes and Perioperative Cardio Vascular Events
|
N/A | |
| Recruiting |
NCT03915314 -
Correlation Between Blood Biomarkers and Postoperative Delirium in Elective Non-Cardiac Surgery.
|