Elderly Clinical Trial
Official title:
The Impact of Routine Measurement of Cardiac Troponin (hsTnT) on Outcome in Elderly Patients Undergoing Major Surgery
To document levels of cardiac troponin hsTnT in patients above 75y undergoing high risk surgery and the relationship between elevated levels and outcome in terms of hospital stay and 30 day mortality.
Elevated troponin (Tn) hsTnT levels occur as a result of myocardial damage and are used in
the diagnosis of myocardial infarction (MI). However, there are multiple different causes
that also result in abnormal Tn levels, such as direct myocardial-cell injury, impaired renal
excretion and sepsis. Because of this, elevated Tn level is a common finding in hospitalized
patients.
Several studies on patients admitted to the intensive care unit (ICU) without MI show that Tn
elevation is a mortality risk factor and an independent predictor of hospital mortality.
Up till now it is not yet known if the routine measurement of Tn in elderly patients
undergoing surgery can significantly improve their outcome and that is the primary aim of
this study. In addition, it is not known what the impact could be if a diastolic function
assessment could be performed peri-operatively.
This study will examine the correlation between elevated Tn levels in elderly patients
undergoing major surgery and their short-term outcome (in-hospital). Before and immediately
after surgery, diastolic function will be assessed by means of transthoracic echocardiography
(TTE).
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