Elderly Clinical Trial
Official title:
Citrulline Supplementation in Elderly Malnourished and Hospitalised Subjects: Effects on Protein Metabolism
The aim of this study is to evaluate the effects of a supplementation of citrulline for three weeks in elderly malnourished and hospitalised subjects on muscle protein synthesis.
Malnutrition in the elderly causes an important public health problem because their response
to re nutrition is highly decreased. Several experimental studies have shown that an amino
acid named citrulline could avoid this, by restoring protein synthesis.
The treated group will receive each morning for three weeks a supplementation of 10 g of
citrulline and the control group, non essential amino acids in iso-nitrogenous quantity to
the 10g of citrulline.
During the three weeks of supplementation, clinical tolerance and physical exercise will be
evaluated regularly.
On the 21st day, whole body protein synthesis rate in the post-absorptive state will be
measured by the isotopic dilution of L-leucine (1-13C expressed in g / kg of lean mass /
24h) as well as other parameters of the protein turn-over in the post-absorptive and
post-prandial state.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
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