Application of Ultrasonic Elastography in Lung Lesions

Elastography Clinical Trial

Official title:

Transthoracic Ultrasound Elastography in Pulmonary Lesions and Diseases

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02636985
• Other study ID #: 201503075RINC
• Status: Completed
• Phase: N/A
• First received: November 24, 2015
• Last updated: December 17, 2015
• Start date: December 2011
• Est. completion date: March 2013

Study information

• Verified date: December 2015
• Source: National Taiwan University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Observational

Clinical Trial Summary

Elastography is an imaging of tissue elasticity or stiffness and is currently emerging as a mainstream tool for ultrasound-based diagnosis. This compressibility property of materials, mathematically expressed as the change in tissue displacement as a function of its distance from the compressing device, is known as strain and is the parameter that is imaged in an elastogram.

Elastography has currently shown promising result in differentiating viscoelastic nature of various organs, which is a consequence of certain underlying diseases.

At present, there are limited literatures revealing the application and feasibility of ultrasonic elastography in lung lesions. This is essentially important as it may serve as an adjuvant to B-mode ultrasound. The investigators aimed at exploring the application and feasibility of ultrasonic elastography on lung lesions.

Description:

Patients performed conventional B-mode ultrasound, subsequently followed by ultrasound elastography. The strain ration was measured and was compared between necrosis, atelectasis, consolidation and tumor.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 45
• Est. completion date: March 2013
• Est. primary completion date: March 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 85 Years

Eligibility

A. Inclusion Criteria:

Patients with radiographic findings of:

1. consolidation

2. obstructive pneumonitis

3. tumors

B. Exclusion Criteria:

1. Patients with poor acoustic window

2. Unable to hold breathing

3. Not cooperative

4. Presence of pleural effusion

Study Design

Observational Model: Case-Only, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Elastography

Locations

Country	Name	City	State
Taiwan	National Taiwan University Hospital	Taipei	Taipei City

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Comparison of strain ratio between necrosis, atelectasis, consolidation and tumor	The strain ratio was measured under ultrasonic elastography. At least three measurements were performed each time and we average all the measurements as the final strain ratio. Independent t test was used for comparison.	Up to 15 months	Yes