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Clinical Trial Summary

EGFR-TKI is the main is the first line therapy for local advanced or metastatic non-small cell lung cancer with EGFR gene mutation. The median progression free survival time is around 11 months with the first generation EGFR-TKI. Patients with acquired resistance with first generation EGFR-TKI usually with EGFR exon 20 mutation (T790M). Change the drug administration maybe prolong patients PFS and evently prolong OS.


Clinical Trial Description

1st generation EGFR-TKI has reversible binding to EGFR, it also bind to T790M in a high dose which is account about 60% patients acquired resistance to the drug. Resistance patients may be benefit to a bolus drug use to block T790M gene. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02575560
Study type Observational
Source Qingdao Central Hospital
Contact
Status Completed
Phase N/A
Start date October 1, 2015
Completion date December 31, 2017

See also
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