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Study on Signal Switch Receptor Modified TIL for the Treatment of Advanced Gynecologic Tumors

Treatment Side Effects Clinical Trial

Official title:
A Clinical Study on Signal Switch Receptor Modified TIL for the Treatment of Advanced Gynecologic Tumors

Clinical Trial Summary

This study is to investigate the safety and efficacy of signal switch receptor modified TIL (GC201 TIL) in patients with advanced gynecologic tumors. Autologous TILs from tumor resections or biopsies are first gene modified(TGF-β receptor or PD-1 gene modified TILs which could transfer the suppression signal surrounding the microenvironment of tumor bed into persistent T cell activation signal) and than expanded before i.v. infusion into the patient after NMA lymphodepletion treatment with hydroxychloroquine(600mg,single-dose) and cyclophosphamide.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05098171
Study type Interventional
Source Shanghai Juncell Therapeutics
Contact Clinical GC
Phone 086-18001759113
Email clinicaltrials@juncell.com
Status Recruiting
Phase Early Phase 1
Start date September 26, 2021
Completion date September 25, 2025
View Details
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