Effect of Drugs Clinical Trial
Official title:
The Off Label Use of Glycopyrrolate in the Adults Intensive Care Unit.
Tracheostomized patients in the ICU can have excessive tracheal secretions due to various
causes as hyperactive airway, irritation of the mucus producing cells and inhibition of the
ciliary functions. Excessive secretions will necessitate frequent suctions which carries the
risk of tracheostomy tube obstruction if not managed properly. Excessive tracheal secretions
may prolong the ICU stay, increase the nurses workload and increase patients morbidity and
mortality.
This clinical trial hypothesizes that the use of glycopyrrolate may decrease the tracheal
secretions and hence avoid such complications.
Patients fulfilling the inclusion criteria will be randomly assigned into one of 2 groups:
Group G (Intervention group): Patients will receive Glycopyrrolate 0.2 mg IV every 8 hours.
Group C (Control group): Patients will receive 2 mL Normal saline every 8 hours.
Both injections will be labelled as drug A and drug B in the satellite pharmacy .
Both the attending physician, nurse and data collector will be blinded to the injection
given.
Measurements data will be collected and recorded daily in the pre-prepared CRF during the
study period.
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