Anesthesia, Local Clinical Trial
Official title:
Ropivacaine 0,2% Plus Dexamethasone Versus Ropivacaine 0,2% Plus Placebo in Modified Pectoral Block - a Randomized, Double-blind, Prospective Trial
To find out if dexamethasone used as adjuvant to ropivacaine, a long-lasting local anesthetic, prolongs the duration of modified pectoral nerve block in women undergoing breast surgery.
Breast surgeries are one of the most common forms of surgery conducted in hospitals, and even
relatively minor interventions can be associated with significant postoperative pain. The
most common surgical procedure for breast cancer is modified radical mastectomy, which means
removing a generous amount of skin and the entire breast with axillary evacuation. According
to the literature, up to 50% of breast surgery patients experience severe acute postoperative
pain, with 10-40% breast cancer patients experiencing pain a year or more after surgery.
Poorly controlled postoperative pain has negative physiological and psychological
consequences. Furthermore, effective acute pain control preserves immune function both by
suppressing surgical stress response and decreasing the need for general anesthetics and
opioids in the perioperative period.
The ultrasound-guided modified, pectoral nerve block is a frequently used, easy, and reliable
technique to provide complete analgesia during and after breast surgery. A major limitation
to its use for postoperative analgesia is that the analgesic effect lasts only a few hours,
after which moderate to severe pain at the surgical site may result in the need for
alternative analgesic therapy. Several adjuvants have been used to prolong the analgesic
duration of peripheral nerve block, including perineural/interfascial or intravenous
dexamethasone.
Our aim is to explore the efficacy of 8 mg dexamethasone added to US-guided modified pectoral
nerve block on postoperative pain in patients undergoing major breast surgery.
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