Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT06106425 |
| Other study ID # |
EEG in neonatal convulsions |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
October 2023 |
| Est. completion date |
October 2024 |
Study information
| Verified date |
October 2023 |
| Source |
Assiut University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Diagnostic and prognostic criteria of EEG in neonatal convulsions at Assiut University
Children Hospital
Description:
The electroencephalogram (EEG) was invented almost 100 years ago and is still a method of
choice for many research questions. It is a graphic representation of the difference in
voltage between two different cerebral locations plotted over time. The scalp EEG signal
generated by cerebral neurons is modified by electrical conductive properties of the tissues
between the electrical source and the recording electrode on the scalp, conductive properties
of the electrode itself, as well as the orientation of the cortical generator to the
recording electrode, (Olejniczak, P et al 2006).
EEG is best used to study the response of the brain to events in the environment or to
internal changes during a seizure. EEG is one of the main tools for obtaining
electrophysiological information about cerebral function, (Fowle AJ, Binnie CD et al 2000).
Research using neonatal electroencephalography (EEG) has been limited by a lack of a
standardized classification system and interpretation terminology.
Electroencephalography (EEG) is an important tool to assess brain function in neonates, for
whom clinical observation alone is often insufficient to accurately evaluate cerebral
function. EEG is used to assess the severity of brain dysfunction in neonates with known or
suspected brain injury; abnormal EEG background features may serve as indicators of
unfavorable long-term prognosis, (Wusthoff CJ, Sullivan J et al 2017).
Seizures are the most frequent neurological event in newborns and clinical data suggest that
etiology is the dominant factor in long term outcome. However, there are consistent
background EEG abnormalities associated to neonatal seizures that are usually related to
unfavorable outcome. For example, the burst - suppression pattern may appear related to many
neonatal neurological disorders and is associated with early and refractory neonatal
seizures, (Nunes ML, Giraldes MM et al 2005).
Also, a normal EEG in a term newborn with hypoxic ischemic encephalopathy (HIE) is associated
with good neurological outcome. (Jose A, Matthai J et al 2013).
The chances of survival of preterm infants have increased markedly during recent decades.
However, despite this improved survival prognosis, several studies have pointed towards the
poor psychomotor outcome of these infants. For example, periventricular leukomalacia is the
most common type of hypoxic-ischaemic brain damage causing poor psychomotor development in
usually very preterm infants. Diagnostic procedures for detecting brain damage in newborn
infants are of two types: bedside and non-bedside techniques. The neuro-developmental outcome
is correlated with the number of positive Rolandic sharp waves seen on the EEG recording,
