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Immunogenetic Profiling of Dupilumab for the Treatment of Atopic Dermatitis

Atopic Dermatitis Clinical Trial

Official title:
Immunogenetic Profiling of Dupilumab for the Treatment of Atopic Dermatitis

Clinical Trial Summary

This is a single-arm, open-label study to examine the effect of dupilumab on the immunologic and genetic environment within atopic dermatitis skin lesions.

Clinical Trial Description

Fifteen subjects with moderate to severe AD will receive dupilumab for a treatment period of 52 weeks (i.e. last injection on week 50). Biopsy samples from AD subjects and surgical discard samples will undergo molecular profiling. Skin swabs and stool samples will be collected and banked for future analysis. The reason to treat patients for 52 weeks is to have the ability to correlate early molecular events with clinical outcomes at week 52. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03293030
Study type Interventional
Source University of California, San Francisco
Contact
Status Completed
Phase Phase 4
Start date October 22, 2018
Completion date February 23, 2023
View Details
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