Ectropion Clinical Trial
Lid retraction is a difficult problem encountered in oculofacial plastic surgery. It can
result from previous surgery, radiotherapy or cicatrizing disease or it may be idiopathic.
Whatever the aetiology, the cosmetic appearance is troublesome to patients and, can be
damaging to the cornea. The definitive therapy for lid retraction is surgical, and often
involves complicated procedures including tissue grafting.
Hyaluronic acid gels (HAG) have been FDA approved for the treatment of facial rhytids by
subcutaneous injection and volume addition. These gels have gained wide popularity in for
cosmetic applications in filling volume deficit areas. Functional applications in the
periorbital area have also been described including the filling of volume deficit
anophthalmic orbits, ectropion and loagophthalmos. Additionally, pilot studies have found
HAG to be useful in correcting both upper and lower eyelid retraction, with good effect.
The purpose of this investigation is to define the clinical utility of HAG correction of
lower eyelid retraction in terms of anatomic (lid position), quantitative (dry eye signs on
cornea) and qualitative effects (symptom severity).
Our hypothesis is that HAG correction of lower eyelid retraction will improve patient
comfort, clinical signs of dry eye and aesthetic self image.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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