Clinical Trials Logo

Clinical Trial Summary

OBJECTIVES:

I. Evaluate the efficacy of octreotide, a somatostatin octapeptide analog, in decreasing gastrointestinal bleeding in patients with hormone-refractory hereditary hemorrhagic telangiectasia or senile ectasia.


Clinical Trial Description

PROTOCOL OUTLINE: Patients are treated with subcutaneous injections of octreotide twice a day. The dose is adjusted based on response.

If there is no requirement for transfusions or intravenous iron for 4 weeks and the hemoglobin is greater than 10 mg/dL, therapy is continued for 1 year. If there is no decrease in bleeding after 10 weeks, the patient is removed from study. ;


Study Design

Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT00004327
Study type Interventional
Source Office of Rare Diseases (ORD)
Contact
Status Completed
Phase Phase 2
Start date January 1995

See also
  Status Clinical Trial Phase
Active, not recruiting NCT02874326 - Octreotide in Patients With GI Bleeding Due to Rendu-Osler-Weber Phase 2
Completed NCT00389935 - Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Phase 2
Active, not recruiting NCT04646356 - Tacrolimus Trial for Hereditary Hemorrhagic Telangiectasia (HHT) Phase 2
Completed NCT04139018 - Timolol Gel for Epistaxis in Hereditary Hemorrhagic Telangiectasia Phase 2
Completed NCT03691142 - Evaluation of Obstetrical and Neonatal Complications in Hereditary Haemorrhagic Telangiectasia (HHT)
Recruiting NCT04404881 - Bevacizumab In Hereditary Hemorrhagic Telangiectasia Phase 2
Completed NCT02977637 - MRA With Feraheme in HHT Phase 1
Completed NCT01485224 - Efficacy of Thalidomide in the Treatment of Hereditary Hemorrhagic Telangiectasia Phase 2
Recruiting NCT06259292 - Comprehensive HHT Outcomes Registry of the United States (CHORUS)
Active, not recruiting NCT04150822 - Hereditary Hemorrhagic Telangiectasia (HHT) Research Outcomes Registry
Recruiting NCT03850964 - Effects of Pazopanib on Hereditary Hemorrhagic Telangiectasia Related Epistaxis and Anemia (Paz) Phase 2/Phase 3
Completed NCT05752253 - Counseling Intervention in Hereditary Hemorrhagic Telangiectasia in the COVID Era. N/A
Not yet recruiting NCT02458703 - Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs With and Without Airflow Obstruction N/A
Completed NCT01752049 - Topical Anti-angiogenic Therapy for Telangiectasia in HHT: Proof of Concept Phase 1/Phase 2
Completed NCT00004649 - Study of the Natural History and Genotype-Phenotype Correlations of Hereditary Hemorrhagic Telangiectasia Patients N/A
Active, not recruiting NCT04874558 - Ultra-low-dose Chest CT for HHT
Completed NCT01031992 - Tranexamic Acid and Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Phase 3
Recruiting NCT05269849 - Sirolimus for Nosebleeds in HHT Phase 2
Completed NCT03572556 - Prospective Descriptive Study of the Angiogenic T Cell Population in Subjects With Hereditary Hemorrhagic Telangiectasia (HHT)
Completed NCT04113187 - Propranolol for Epistaxis in Hereditary Hemorrhagic Telangiectasia Patients Phase 3