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Eclampsia clinical trials

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NCT ID: NCT04656665 Not yet recruiting - Pre-Eclampsia Clinical Trials

The Effectiveness of Aspirin on Preventing Pre-eclampsia

Start date: March 15, 2021
Phase: Phase 4
Study type: Interventional

This study will explore the effectiveness of low-dose aspirin on preventing pre-eclampsia in high-risks pregnant women by comparing the incidence of pre-eclampsia and pregnancy outcomes.

NCT ID: NCT04424693 Not yet recruiting - Pre-Eclampsia Clinical Trials

Comparing the Incidence of Preeclampsia Between Pregnant Women Receiving Tdap Vaccinations at Week 28 or at Week 36

Start date: December 1, 2020
Phase: Phase 4
Study type: Interventional

Preeclampsia is a significant medical condition occurring in 3-8% of pregnancies and impacts deleteriously both maternal and fetal health. An important discovery has been made by Dr Craig D Scoville showing that early Tdap vaccinations in pregnancy can reduce the incidence of preeclampsia by more than 50%. A prospective clinical research trial is proposed and urgently needed to validate this finding and thereby make a significant contribution in reducing the incidence of this common and severe complication of pregnancy.

NCT ID: NCT04310683 Not yet recruiting - Pre-Eclampsia Clinical Trials

Natural Cycle or Stimulated Cycle Versus Hormone Replaced Cycle for Pre-eclampsia Rate

Start date: November 10, 2020
Phase: N/A
Study type: Interventional

Recent sutdies indicate that the existence of corpus lutein in the ovary is a key point to prevent preeclampsia, and patients undergoing FET with hormone replaced cycle have no corpus lutein and the absence of corpus lutein significantly increases the risk of preeclampsia in these patients. We aim to conduct a single center randomized trial study to compare the preeclampsia rate between the natural cycle and the hormone replaced cycle in patients undergoing FET.

NCT ID: NCT04287998 Not yet recruiting - Pre-Eclampsia Clinical Trials

Role and Expression of MXRA5 in Placental Connective Tissue Remodelling in Preeclampsia

Start date: April 1, 2020
Phase:
Study type: Observational

1. To measure the level of expression of MXRA5 and ANXA4 genes in preeclampsia (PE). 2. To detect the effect of heavy metals (lead (Pb) and arsenic (AR)) on these two genes in the pathology of PE. 3. To explore the association of the previous two genes with the heavy metals in link with Phosphoinositide 3-kinases/Protein Kinase B (PI3K/AKT) pathway. 4. To detect Syndecan-1 by immunohistochemical antibodies. 5. To define the role of extracellular matrix remodelling in PE.

NCT ID: NCT03917342 Not yet recruiting - Pre-Eclampsia Clinical Trials

Electroencephalographic Effects of Spinal Anaesthesia During Caesarean Delivery in Preeclampsia

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

Neuraxial anesthesia has been associated with delayed brainstem conduction and decreasing afferent sensory transmission, thereby modifying reticulo-thalamo-cortical mechanisms regulating arousal. The state of entropy measured by EEG-monitors has detected sedative effects associated with neuraxial anaesthesia in healthy volunteers, as well as during caesarean delivery. Entropy is a measure of the irregularity or disorder of a brains activity - sedation leading to a decrease of irregularity or disorder in the EEG.The aim of this pilot study is to prospectively assess the effect of spinal anaesthesia in healthy and preeclamptic parturients on brain activity. Decreased epileptiform activity in patients with preeclampsia would suggest that early neuraxial analgesia in labouring preeclamptic patients is beneficial, and may protect against neurological complications.

NCT ID: NCT03549767 Not yet recruiting - Clinical trials for Preeclampsia and Eclampsia

Springfusor for Administration of Magnesium Sulphate in Preeclampsia and Eclampsia

Start date: June 2018
Phase: N/A
Study type: Interventional

Magnesium Sulphate is the drug of choice for prevention and treatment of seizures in preeclampsia and eclampsia. It is administered parenterally by intravenous (IV) and or intramuscular (IM) routes. The IM regimen requires repeated painful injections which may be a barrier to optimal utilization whereby, there is frequent omission of some doses or increased interval between maintenance doses and low patient acceptability of magnesium. The study plans to assess the acceptability and safety of Springfusor device in the administration of magnesium sulphate in preeclampsia and eclampsia.

NCT ID: NCT03349671 Not yet recruiting - Pre-Eclampsia Clinical Trials

Predictors of Intrauterine Growth Restriction

Start date: October 2018
Phase:
Study type: Observational

The main objectives of modern antenatal care programs are to identify high risk pregnancies then to predict any possibility of adverse pregnancy outcome as early as possible. The earliest attempts to achieve this goal were possible with the introduction of ultrasound in obstetrical practice in the 1950s. A breakthrough that enabled obstetricians to directly visualize the fetus, placenta and amniotic fluid. At first 2-dimensional (2D) imaging was employed whereby fetal biometry and placental location were detected. Later on, Doppler measurements & 3-dimensional (3D) representation became feasible further revolutionizing this area

NCT ID: NCT03302260 Not yet recruiting - Pre-Eclampsia Clinical Trials

Identifying Methods for Postpartum Reduction of Vascular Events: Pilot Randomized Controlled Trial

IMPROVE
Start date: September 2019
Phase: N/A
Study type: Interventional

IMPROVE is a pilot RCT with a behavioral intervention component (CardioPrevent program). The primary objectives of this pilot study are to assess the feasibility of the implementation of a postpartum CVD prevention lifestyle program in women with a HDP as well as the transferability and fidelity of the Ottawa-based CardioPrevent® program to a centre in Calgary (following a "Train the Trainer" model). Secondary objectives include an initial evaluation of the effectiveness of this intervention on clinical outcomes and measures of microvascular function between study arms at one year.

NCT ID: NCT03214393 Not yet recruiting - Pre-Eclampsia Clinical Trials

Certain Maternal Antibodies in Relation to Doppler in Hypertension With Pregnancy

Start date: August 1, 2017
Phase: N/A
Study type: Observational

Relation of certain maternal serum antibodies to Doppler changes will be studied in cases suffering from hypertension with pregnancy.

NCT ID: NCT02706158 Not yet recruiting - Pre-eclampsia Clinical Trials

Dietary Intervention Program for Pre-eclampsia in Women at Risk

Start date: April 2016
Phase: N/A
Study type: Interventional
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