Ebola Virus Disease Clinical Trial
Official title:
A Phase 1 Double-blind, Dose-escalation, Clinical Trial to Evaluate the Safety, Tolerability and Immunogenicity of the Ebola Adenovirus Vector Vaccine (Ad5-EBOV) in Healthy Adults in China
Since its first outbreak occurred in 1976, Zaire Ebola virus have been associated with 14
outbreaks reported up to 2014. The Zaire Ebola virus in 2014 causing the most serious
outbreak was considered to be a new epidemic strain, with GP homology of the gene was only
97.6%, compared to the GP gene of the strain in 1976. This investigational Ad5-EBOV vaccine
was developed according to the 2014 epidemic Zaire strain and formulated as freeze-dry
products which could be stored at 4℃.
This is a single center, double-blind, placebo control, dose-escalation phase 1 clinical
trial. This study will determine the safety and side-effect profile, and immunogenicity of
an investigational Ad5-EBOV vaccine.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Prevention
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