Eating Disorders Clinical Trial
Official title:
An Investigation of the Effects of Cognitive and Emotional Functioning on Treatment Outcomes
The investigators are interested about the degree to which individuals can persist with
individualized treatment goals when their cues (external such as food, or internal such as
anxiety) are high for impulsive/maladaptive behavior (e.g., purging, not eating, etc.). The
investigators want to find specific high-difficulty situations in which to assess whether
participants remain mindful of the big picture and are willing to work toward therapeutic
goals. Also, the investigators want to rate the participants degree of success (e.g.,
proportion of calories eaten) assessed more objectively.
The theory is that working memory capacity (WMC) modulates the ability to keep longer-term
goals in mind when faced by current stress/temptations. For example, the ability to control
drinking when one has an implicit urge to drink is predicted by WMC. The ability to apply a
novel emotional regulation skill at a time of stress is also predicted by WMC. Indeed, the
generic ability to pursue goals in the future (as assessed by the discounting of the value of
future goals) is reliably predicted by WMC. There is also evidence that activation of brain
regions associated with WMC (by direct activation of the dorsolateral prefrontal cortex via
transcranial magnetic stimulation (TMS), or by having a person complete a relevant cognitive
task) improves delay discounting.
Accordingly, the investigators are proposing a study that both assesses the link between WMC
and relevant the clinical measures noted above, as well as changes in these measures
following activation of WM with a cognitive prime (WM task). The overall design calls for an
initial WMC assessment, followed by randomization to complete 3 days of a WM prime and then 3
days of a no prime group, or vice versa. The investigators then assess the clinical outcomes
noted above across the following 6 days, with a WM prime first or no prime first occurring
prior to the targeted behaviors. The investigators will prime WM prior to participant's
evening meal, with the WM intervention offered during the free time before this meal.
n/a
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