Eating Disorder Clinical Trial
Official title:
Validation of the Concept of the Autoantibodies Directed Against the Neuropeptides Involved in Food Intake Regulation on the Incidental Cases of Eating Disorders
This study should lead to the validation of the concept of the autoAc directed against the neuropeptides involved in food intake regulation.
Eating disorders are a public health issue. It has been recently reported the importance of
immune system modifications in eating disorders physiopathology, involving autoantibodies
directed against neuropeptides regulating food intake. A recent study of laboratory INSERM
1073 showed the existence of an intestinal bacterial protein exhibiting structural
similarities with α-MSH: ClpB. The autoAc directed against the latter also react with α-MSH
because of these similarity of structures, thus leading to a potential digestive origin of
these autoAc. To consolidate this new etiopathogenic assumption, a large clinical study is
necessary with analysis of patients autoAc profiles. a monocentric study with inclusion of
240 patients over 2 years and 80 healthy volunteers is proposed.
This study should lead to the validation of the concept of the autoAc directed against the
neuropeptides involved in food intake regulation. Nutritional modulations (probiotic,
amino-acid…) could constitute an interesting therapeutic perspective in the future.
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