Brain Function in Adolescent Eating Disorders and Healthy Peers

Eating Disorder Clinical Trial

Official title:

Neurocircuitry of Temperament and Motivated Behavior in Adolescent Eating Disorders

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03347565
• Other study ID #: 170664
• Status: Active, not recruiting
• Start date: July 21, 2017
• Est. completion date: November 2024

Study information

• Verified date: November 2023
• Source: University of California, San Diego
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study of adolescent eating disorders (ED) will examine the association of temperament-based classifications, brain activation during incentive processing, and ED symptoms at time of scan and 1 year later to better understand the neurobiology and symptoms of ED. We will recruit 150 females currently ill with an ED and 50 controls ages 14-17 to investigate how temperaments reflecting greater inhibition, impulsivity, or effortful control correspond to 1) clinical symptoms and 2) the brain's response to anticipation and outcome of salient stimuli, and 3) by collecting follow-up clinical data one year later, identify how temperament-based subtypes predict ED symptom change (e.g., clinical prediction). Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 155
• Est. completion date: November 2024
• Est. primary completion date: November 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 14 Years to 17 Years

Eligibility

Inclusion Criteria:

• Female

• Meet DSM-V criteria for an Eating Disorder or Never met criteria for an Eating disorder

• Medically stable

• Post-Pubertal (must have started menses, but subsequent loss of menses secondary to ED is fine).

Exclusion Criteria:

• Psychotic illness/other mental illness requiring hospitalization

• Current dependence on drugs or alcohol

• Physical conditions known to influence eating or weight (e.g, diabetes mellitus, pregnancy).

• On psychoactive medication

• Organic brain syndromes, delirium, psychotic disorders, or intellectual disability

• Neurological or medical disorders such as seizure disorder

• Any contraindication to undergoing an MRI

• Major depressive disorder

• Left handed

Related Conditions & MeSH terms

• Eating Disorder
• Feeding and Eating Disorders

Locations

Country	Name	City	State
United States	University of California San Diego	San Diego	California

Sponsors (1)

Lead Sponsor	Collaborator
University of California, San Diego

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain function	Functional Magnetic Resonance imaging will be used to assess brain activation associated with inhibition, impulsivity, and control	1 year (fMRI Scan)