the Association Between Obesity and Early Puberty

Early Puberty Clinical Trial

Official title:

Polymorphisms in Obesity-related Genes Are Associated With Risk of Early Puberty in Han Chinese Girls

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04317014
• Other study ID #: szCDC_2
• Status: Completed
• Start date: September 1, 2016
• Est. completion date: June 4, 2019

Study information

• Verified date: March 2020
• Source: Shenzhen Center for Disease Control and Prevention
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

childhood obesity and early puberty are closely related, but existing reports usually focus on their relationship from the perspective of phenotype. This study was designed to investigate the association between obesity-related genic polymorphisms and the risk of early puberty in Chinese Han girls.

Description:

the genotypes of obesity-related SNPs were determined and the unstimulated luteinizing hormone, follicle stimulating hormone and estradiol levels were also detected.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 628
• Est. completion date: June 4, 2019
• Est. primary completion date: May 20, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 7 Years to 10 Years

Eligibility

Inclusion Criteria:

• Clinical diagnosis of central precocious puberty or early and fast puberty.

Exclusion Criteria:

• The participants who were not the first visit to the hospital and had been treated before.

• The participants who were with endocrine disorders.

Related Conditions & MeSH terms

• Early Puberty
• Puberty, Precocious

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Shenzhen Center for Disease Control and Prevention

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	genotypes of SNPs in the obesity-related genes	the obesity-related SNPs in the LRRN6C, MAF, CYP27A1 and ETV5 genes are selected and the genotypes of these SNPs are determined with a MassARRAY system.	3 months