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Early Psychosis clinical trials

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NCT ID: NCT06192602 Active, not recruiting - Psychotic Disorders Clinical Trials

Effects of an Acceptance-based Medication Adherence Therapy for Recent-onset Psychosis

AIM_AT
Start date: March 1, 2022
Phase: N/A
Study type: Interventional

This randomized controlled trial aimed to examine the effectiveness of a 10-session acceptance-based, insight-inducing medication adherence therapy (AIM-AT) program for recent-onset psychosis (in addition to usual care) over a 12-month follow-up (i.e., at immediate, 6-month, and 12-month post-intervention).

NCT ID: NCT06032182 Recruiting - Early Psychosis Clinical Trials

PSYCHE Cognitive Remediation & Social Recovery Study

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

This study is a pilot feasibility study embedded in the Early Intervention in Psychosis (EIP) services in Ireland. It explores the feasibility and acceptability of a combined cognitive remediation training and social recovery therapy intervention.

NCT ID: NCT04592042 Completed - Emotional Distress Clinical Trials

Intervention to Improve Coping With Negative Emotions in Patients With Psychosis (Feel-Good-Study)

Start date: January 8, 2021
Phase: Early Phase 1
Study type: Interventional

The aim of the present single-centered pre-post study is to assess the feasibility and to investigate the putative efficacy of an emotion-oriented group intervention for patients with psychosis. Patients with early psychosis in an inpatient unit receive a manualized group intervention focussing on emotional stability and emotion regulation (8 weekly sessions). Assessment will be performed at pre-therapy, post-therapy (after eight sessions and four weeks) and after a follow-up period of 12 weeks (8 weeks post therapy) and includes personal therapy goals and their realization, psychopathology, social functioning and emotion regulation skills as a putative mediator of change.

NCT ID: NCT04411225 Recruiting - Early Psychosis Clinical Trials

Effects of Cannabidiol (CBD) Versus Placebo as an Adjunct to Treatment in Early Psychosis

Start date: June 1, 2022
Phase: Phase 3
Study type: Interventional

This is an outpatient, single center, between-group, double blind, placebo controlled design. Approximately 120 adolescents and adult patients will be randomized to either have their treatment augmented with Cannabidiol Oral Solution (CBD) or with a matching CBD placebo for 8 weeks. The study will examine CBD as an augmentation strategy in early psychosis. It is hypothesized that CBD will improve symptoms, neurocognition, markers of inflammation and eating behaviors. Importantly, moderators and mediators of the CBD effects will be explored.

NCT ID: NCT04373590 Completed - Early Psychosis Clinical Trials

Decision-making and Decision Support Among Emerging Adults With First Episode Psychosis

Start date: February 27, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the impact of an antipsychotic medication decision aid and interpersonal and cognitive factors, such as attachment style and motivation, on emerging adults' ability to engage in shared decision making regarding their medications.

NCT ID: NCT04317807 Recruiting - Early Psychosis Clinical Trials

R33: Levetiracetam in Early Psychosis

Start date: August 27, 2020
Phase: Phase 2
Study type: Interventional

This is a 12-week study of levetiracetam added to a second generation antipsychotic in early psychosis patients who have been ill for less than 5 years and continue to experience psychotic symptoms despite at least 8 weeks of antipsychotic treatment. Levetiracetam (Keppra) is a medication approved for the treatment of epilepsy; it reduces excessive activity in the brain. This study will test the hypotheses that adding levetiracetam will improve psychotic symptoms that are unresponsive to antipsychotic treatment and will protect the brain from atrophy (volume loss). .

NCT ID: NCT04166019 Active, not recruiting - Psychotic Disorders Clinical Trials

Effect of a Peer-led Self-management Program for Recent-onset Psychosis

PLSMI
Start date: December 1, 2020
Phase: N/A
Study type: Interventional

This randomized controlled trial is to test the effectiveness of a peer-led self-management program (PLSMI) for people with recent-onset psychosis in the community over 18-month follow-up, compared with a conventional psychoeducation group and routine community mental healthcare.