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Clinical Trial Summary

The goal of this randomized controlled study is to compare the outcome of preterm infants who will receive the standard antibiotic prophylaxis for EOS or Procalcitonin/Presepsin-guided antibiotic prophylaxis of early onset sepsis (EOS). The main question it aims to answer is: • Does Procalcitonin/Presepsin-guided antibiotic prophylaxis of (EOS) increase survival without major morbidities, including IVH >3 grade, PVL, ROP >3 grade in either eye, NEC >2 grade, BPD, or LOS. Infants with gestational age between 25+0 and 31+6 weeks of gestation or a birth weight <1500 g will be eligible for enrollment in the study. Participants will be randomized to receive standard antibiotic prophylaxis for EOS (standard group) or to receive antibiotic prophylaxis for EOS on the basis of PCT/P-SEP measured within 3 h of life (intervention group).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05796115
Study type Interventional
Source University of Florence
Contact Carlo Dani
Phone 0039 055 7948421
Email carlo.dani@unifi.it
Status Not yet recruiting
Phase N/A
Start date April 1, 2023
Completion date September 30, 2025

See also
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