| Eligibility |
Inclusion criteria for EOAD patients will be recruited from the LEADS trial with the
following:
- 40 to 64 years of age
- Meets NIA-AA criteria for mild cognitive impairment (MCI) due to AD or probable AD
dementia.
- Have a global CDR score of = 1.0
- Have capacity to provide informed consent (ICF) or has a legal authorized
representative or guardian who provides IC.
- Amyloid positive status (PET scan with evidence of elevated amyloid)
- Must have a study partner (informant) who spends a minimum average of 10 hours per
week with the participant (e.g., family member, significant other, friend, and
caregiver) who is generally aware of the participants' daily activities and can
provide information about the participant's cognitive and functional performance. If
the participant does not have a study partner who spends 10 face-to-face hours per
week, other arrangements for identifying a viable study partner will be granted on a
case-by-case basis by the Site PI.
- Not pregnant or lactating. Women must be two years post-menopausal, be surgically
sterile, or have a negative pregnancy test prior to each PET scan
- Fluent in English.
Exclusion Criteria:
- Meets core clinical criteria for non-AD dementia.
- Two or more first degree relatives with a history of EOAD suggestive of autosomal
dominant transmission, unless known pathogenic mutations in APP, PSEN1, PSEN2 have
been excluded.
- Known mutation in an ADAD gene (APP, PSEN1, PSEN2) or other autosomal dominant genes
associated with other neurodegenerative disorders.
- MRI scans with evidence of infection or focal lesions, cortical strokes, multiple
lacunes (single lacune is allowable unless it meets criteria for strategic lacune
affecting cognition)
- Any significant systemic illness or unstable medical condition, which could lead to
difficulty complying with the protocol (at the discretion of the Site PI)
- Medical history of a brain disorder other than the disorder causing dementia except
for headache.
- Deemed ineligible by the Site PI for any other reason.
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