Early Gastric Cancer Clinical Trial
Official title:
OLGA Stage is More Appropriate in Predicting Early Gastric Cancer Than Endoscopic Gastric Atrophy Classification and OLGIM Stage: A Prospective Study
The aim of the present study was to evaluate characteristics of background mucosa in early gastric cancer (EGC), and to seek for the optimal assessment for EGC screening.
Japanese endoscopic gastric atrophy (EGA) classification, operative link on Gastritis
Assessment (OLGA), operative link on intestinal metaplasia assessment (OLGIM) and gastritis
pattern are used in evaluating the severity of gastritis and intestinal metaplasia in
different countries, which are risk factors of gastric cancer. The aim of the present study
was to evaluate characteristics of background mucosa in early gastric cancer (EGC), and to
seek for the optimal assessment for EGC screening.
A prospective study was conducted encompassing EGC patients (cases) and non-EGC patients
(controls). All patients were performed endoscopic examination and systematically biopsied.
Outcome measures were assessed and compared, including EGA classification as well as the
OLGA/OLGIM assessment. Helicobacter pylori(H. pylori) status was detected in the meantime. A
stepwise logistic regression model was performed to analyze correlations between EGA, OLGA,
OLGIM and EGC.
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Observational Model: Case Control, Time Perspective: Prospective
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