E03.155.253 Clinical Trial
Official title:
The Modified Foldes-Biro Equation Used in Patients Under General Anaesthesia for the Measurement of Oxygen and Anaesthetic Agent Uptake
The primary aim is to confirm the efficacy of a new non-invasive method for measuring the
oxygen uptake during general anesthesia of patients undergoing surgery under cardiopulmonary
bypass. The method has already been successfully tested in the laboratory under controlled
conditions. In the patient group chosen, oxygen uptake is simultaneously calculated, for
comparison purposes, from monitoring measurements made routinely as part of normal patient
care in these cases, using a pulmonary artery catheter - an invasive technique from which
severe complications occasionally arise, including death.
A secondary aim is to elucidate the time course of uptake of the anaesthetic vapor,
isoflurane, during this kind of surgery.
In a series of 30 patients undergoing cardiopulmonary bypass, the change in nitrogen
concentration between fresh gas entering the anesthetic breathing system and the exhaust gas
leaving it in an otherwise closed system is used to determine total gas uptake by the
principle of insoluble gas dilution. Oxygen and anaesthetic agent uptakes are then
automatically determined by a computer directly linked to a rapid gas analyzer, every 15
seconds.
As a control, oxygen is calculated using the reverse Fick method. Measured arterial and
mixed venous oxygen saturations were used to do this, and the cardiac output which was
determined by thermodilution.
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Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06232980 -
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|
N/A |