Evaluation of the Electronic Cigarette Withdrawal Syndrome

Status Recruiting

Clinical Trial Summary

The goal of this project is to rigorously evaluate the nature of e-cigarette withdrawal in exclusive e-cigarette users during a monitored abstinence period and the role of nicotine in the expression of this withdrawal syndrome.

Clinical Trial Description

This project will use a rigorous residential laboratory design to evaluate e-cigarette withdrawal expression and experimentally determine the role of nicotine in this syndrome. Healthy adults who exclusively use e-cigarettes will undergo monitored e-cigarette abstinence over seven days (1 week) in a residential unit. The investigators will evaluate the contribution of nicotine to withdrawal expression by assigning participants to one of three conditions: active nicotine patch, placebo patch control, or no patch to control for expectancies. Standardized behavioral and biological measures associated with withdrawal including patient report, cognitive task performance, and biometrics will be collected throughout to establish a rigorous timecourse of withdrawal and evaluate the contribution of nicotine to these symptoms. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06066996
Study type	Interventional
Source	Johns Hopkins University
Contact	Justin Strickland, Ph.D.
Phone	4105501975
Email	jstric14@jhmi.edu
Status	Recruiting
Phase	Early Phase 1
Start date	November 28, 2023
Completion date	August 31, 2028

View Details

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