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Clinical Trial Summary

This pilot sensory experiment will examine cooling from comparable concentrations of WS-3 and menthol to determine appropriate concentrations to use in the main study.


Clinical Trial Description

This pilot study will establish low and high concentrations of both WS-3 and menthol concentrations to test in the main study. An anticipated 30 adult e-cigarette users will participate in one laboratory session during which participants will be exposed to e-liquids containing five different concentrations of two different cooling flavors without nicotine (10 e-liquids total). Participants will rate "coolness" using the generalized Labeled Magnitude Scale (gLMS). Using averages of participant ratings, we will select a low concentration of each constituent that is rated as more than "barely detectable" but less than "moderate" to ensure that cooling is weak but clearly perceptible. For the high concentration of each constituent, we will select a concentration that on average falls between "strong" and "very strong" to identify a strong cooling sensation while avoiding sensations that would also be uncomfortable. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05932693
Study type Interventional
Source Yale University
Contact Danielle Davis, PhD
Phone 203-974-7607
Email danielle.davis@yale.edu
Status Not yet recruiting
Phase N/A
Start date June 2024
Completion date June 2025

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