Dystonia Clinical Trial
Official title:
Can Short Latency Afferent Inhibition Give us Clues to Better Dystonia Treatments?
This is a research study using transcranial magnetic stimulation (TMS) to investigate
interactions between the sensory system and the motor cortex in primary generalized dystonia
(DYT1 dystonia) subjects who undergo deep brain stimulation (DBS) surgery.
The sensory system is the body's sense organs - smell, sight, sound, etc. - and the motor
cortex is the part of your brain where nerve impulses control voluntary muscle activity.
The cause of DYT1 dystonia is not clear. DYT1 dystonia symptoms include abnormal posture or
repetitive twisting movements affecting one body part; in some patients, the entire body can
twist and contort painfully. Magnetic resonance imaging (MRI) studies are normally used to
evaluate changes in brain structure in DYT1 dystonia. Transcranial magnetic stimulation
(TMS) is a painless, non-invasive method to test how your brain conducts electrical messages
to the rest of your body, including your muscles.
If you are a DYT1 dystonia patient, then this study involves up to three visits. The first
visit (before DBS surgery) will last about 4 hours and the second and third visits (after
DBS surgery) will last about 4 hours as well. These visits will include a complete physical
and neurological exam, video recorded dystonia and mood rating scales, followed by
electromyography (EMG) and TMS sessions. Subjects who have already undergone DBS surgery may
participate in applicable visits based on the length of time since their DBS surgery.
If you are a control subject, this study involves one visit, about 4 hours long. This visit
will include TMS and EMG sessions.
;
Observational Model: Case Control, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01433757 -
Ampicillin for DYT-1 Dystonia Motor Symptoms
|
Phase 1 | |
| Recruiting |
NCT00971854 -
Alteration of Deep Brain Stimulation Parameters for Dystonia
|
N/A | |
| Enrolling by invitation |
NCT00355927 -
Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.
|
N/A | |
| Completed |
NCT00169338 -
Pallidal Stimulation in Patients With Post-anoxic and Idiopathic Dystonia
|
Phase 2 | |
| Completed |
NCT00004421 -
Deep Brain Stimulation in Treating Patients With Dystonia
|
Phase 2/Phase 3 | |
| Terminated |
NCT03270189 -
Effect of the Visual Information Change in Functional Dystonia
|
N/A | |
| Recruiting |
NCT02583074 -
Clinical Trial of STN-DBS for Primary Cranial-Cervical Dystonia
|
N/A | |
| Recruiting |
NCT06117020 -
Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals
|
Phase 1 | |
| Completed |
NCT01432899 -
Studying Childhood-Onset Hemidystonia
|
||
| Completed |
NCT04948684 -
Efficacy of Botulinum Toxin for the Treatment of Dystonia Associated With Parkinson's Disease and Atypical Parkinsonism
|
||
| Completed |
NCT05106816 -
The Effects of Vibrotactile Stimulation in Patients With Movement Disorders
|
N/A | |
| Recruiting |
NCT05027997 -
Exploratory Study of Dipraglurant (ADX48621) for the Treatment of Patients With Blepharospasm
|
Phase 2 | |
| Completed |
NCT00465790 -
Research of Biomarkers in Parkinson Disease
|
Phase 0 | |
| Active, not recruiting |
NCT00142259 -
Efficacy and Safety of DBS of the GPi in Patients With Primary Generalized and Segmental Dystonia
|
Phase 4 | |
| Recruiting |
NCT05663840 -
Effects of Exercise on Dystonia Pathophysiology
|
N/A | |
| Not yet recruiting |
NCT06038097 -
Efficacy and Safety of Radiofrequency Pallidotomy in the Management of Dystonia
|
N/A | |
| Recruiting |
NCT04286308 -
Cortical-Basal Ganglia Speech Networks
|
N/A | |
| Active, not recruiting |
NCT03582891 -
The Motor Network in Parkinson's Disease and Dystonia: Mechanisms of Therapy
|
N/A | |
| Completed |
NCT03318120 -
Exercise Training in Dystonia
|
N/A | |
| Completed |
NCT04568681 -
Deep Brain Stimulation Effects in Dystonia
|