Dystonia Clinical Trial
Official title:
Alteration of Deep Brain Stimulation Parameters for Dystonia- A Double Blinded Randomised Controlled Trial
Deep brain stimulation (DBS) involves placing electrodes into the brain. Through these
electrodes, artificial electrical signals are chronically delivered into deep brain regions
in order to alter abnormal brain activity. The artificial electrical signals are generated
by a battery that is inserted under the skin of the chest. DBS is used to treat several
disorders of movement, including dystonia. In dystonia, the electrodes are inserted into a
brain region called the globus pallidus.
Globus pallidus stimulation can be very effective therapy for dystonia. However not all
patients are equally responsive and therapeutic outcomes can be frustratingly variable. The
reason for this variability is unclear. Such variability in response may need to be met by
tailoring stimulation to individual patients.
Another issue with deep brain stimulation is battery life. Eventually, batteries become
depleted and need to be replaced. Such battery replacements require an operation, hospital
stay and the risk of introducing infection. The high electrical energy that has been used to
treat dystonia means that batteries are typically replaced every year or two.
The artificial electrical signals of deep brain stimulation are delivered with three
parameters; frequency (Hertz - Hz), voltage (volts) and pulse width (microseconds). It has
recently been reported that lower frequency stimulation, at 60Hz rather than 130Hz, can be
used effectively to treat dystonia. Such 60Hz stimulation may be more effective for some
patients than others. The lower energy demands of 60Hz stimulation would also greatly
improve battery life (potentially doubling battery life).
The aim of this study is to assess if 60Hz stimulation is more effective in ameliorating the
dystonia of patients who have responded poorly to 130Hz pallidal stimulation. The current
status of the evidence is one of clinical equipoise (uncertainty) and therefore suits a
double blinded randomised trial.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | February 2010 |
Est. primary completion date | January 2010 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Primary dystonia (focal cervical or generalised dystonia) who are receiving chronic (>1 year) bilateral pallidal stimulation but have had poor therapeutic responses (< 50% improvement in relevant dystonia severity rating scale*) despite confirmation of accurate electrode position. - Able to understand study requirements - able to provide consent. - Relevant dystonia rating scales: Cervical dystonia - severity subsection of the Toronto Western Hospital spasmodic torticollis rating scale; Generalised dystonia - severity section of the Burke Fahn Marsden rating scale. Exclusion Criteria: |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United Kingdom | University of Oxford, Nuffield Department of Surgery | Oxford | Oxfordshire |
Lead Sponsor | Collaborator |
---|---|
University of Oxford |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | To assess if the stimulation frequency of 60 Hz is superior to 130 Hz for patients with primary dystonia who have responded poorly to standard 130 Hz pallidal stimulation | 6 months | No | |
Secondary | Assess any potential changes in anxiety, mood, cognition | 6 months | No |
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