Task-dependent Operation of a Mechanism Intracortical Inhibition in Dystonia

Dystonia, Primary Clinical Trial

— LICIdystonie  

Official title:

Task-dependent Operation of a Mechanism Intracortical Inhibition in Dystonia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03381456
• Other study ID #: 2013_51
• Secondary ID: 2014-A00244-43
• Status: Completed
• Phase: N/A
• First received: December 18, 2017
• Last updated: December 18, 2017
• Start date: April 2015
• Est. completion date: April 2017

Study information

• Verified date: December 2017
• Source: University Hospital, Lille
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Cortical excitability depends on inhibitory mechanisms efficiency among which long latency intracortical inhibition (LICI) can be studied by paired pulses transcranial magnetic stimulation (TMS). Some recent evidences suggest that LICI may be one of the mechanisms by which the motor comment is adapted to the ongoing motor task with LICI strength being dependent on task complexity. In writer cramp and musician cramp, two forms of dystonia, the cortical excitability is not correctly modulated in some complex gestures. the hypothesis is that this task dependent perturbation of excitability in writer cramp could be due to a lack of LICI efficiency.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: April 2017
• Est. primary completion date: April 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Patient with hand dystonia : writers cramp

• Subject affiliated to social security regimen.

For healthy volunteers :

• Healthy volunteer without neurological disorders based on sensorimotor examination.

• Subject affiliated to social security regimen.

Exclusion Criteria :

• Subject unable to receive informed consent (dementia).

• Contraindication to Transcranial Magnetic Stimulation(TMS) (epilepsia, intracranial metalic foreign object, hearing device, cochlear implant).

• Patient using a psychotrope treatment.

• Patient under guardianship or curatorship.

• Pregnant or nursing women.

• Patient with a cardiac stimulator.

For healthy volunteers only :

• Abnormal neurological evaluation based on sensorimotor examination or neurological history ( epilepsy, stroke ; brain or spinal cord surgery ; history of neurological disease affective sensitive and motor control)

Related Conditions & MeSH terms

• Dystonia
• Dystonia, Primary
• Dystonic Disorders

Intervention

Other:
• LICI
Paired pulse TMS to measure LICI and late cortical disinhibition

Locations

Country	Name	City	State
France	Hôpital Roger Salengro, CHRU de Lille	Lille

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Lille

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	long-interval intracortical inhibition (LICI) level	Amount of inhibition at interstimulus intervals of between 50 to 300ms	Baseline