Role of Oxytocin in Telling and Detecting Lies

Dyssocial Behavior Clinical Trial

Official title:

Role of Oxytocin in Telling and Detecting Lies

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT02361177
• Other study ID #: 2013-11-0033
• Status: Withdrawn
• Phase: Phase 0
• First received: February 5, 2015
• Last updated: June 9, 2016
• Start date: January 2016
• Est. completion date: April 2016

Study information

• Verified date: June 2016
• Source: University of Texas at Austin
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

The investigators are interested in the impact of intranasal oxytocin in unethical behavior.

Description:

The objective of this project is to further explore the role of oxytocin in moral judgment and ethical behavior. Oxytocin is a peptide hormone produced in a variety of hypothalamic neurons. It is released into the brain or brought into general circulation through sensory stimuli in a pulsatile fashion. In social psychology research, oxytocin is hypothesized to coordinate both the causes and effects of positive social interactions in a biofeedback loop.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: April 2016
• Est. primary completion date: April 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Male

Exclusion Criteria:

• _____ _____BP > 130/85, HRT > 95 (can be included at discretion of study physician/designee)

• _____History of seizures

• _____Neurological Disorder

• _____Current psychiatric disorder

• _____Previous psychiatric disorder (can be included at discretion of PI)

• Date last episode (if > 1 year, include; if <1 year, at discretion of PI)

• _____Current use of psychoactive drugs

• _____Previous use of psychoactive drugs (can be included at discretion of PI) _____Date last medicated_____ _____Type of medication___________________________________

• _____Current use of anticoagulants

• _____Current use of corticosteroids

• _____Previous head trauma (can be included at discretion of PI)

• _____Alcoholism or substance abuse

• _____Carcinoma of the breast or prostate

• _____Renal or Hepatic diseases

• _____Chronic lung diseases

• _____Cancer

• _____Liver problems

• _____Hypertension/Cardiac diseases

• _____Cardiovascular Disease

• _____Nephritis

• _____Diabetes (use of insulin) /Obesity

• _____Endocrine disease or malignancy

• _____Asthma (can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study)

• Medication

• Frequency of episodes____ _____Date of last episode_____

• _____Migraines(can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study)

• Medication _____Frequency of migraines_____ _____Date of last migraine_____

• _____High levels of physical contact with women or children

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Dyssocial Behavior

Intervention

Drug:
• Oxytocin
Intranasal oxytocin is hypothesized to amplify the influence of social norms on unethical behavior.

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
University of Texas at Austin	Harvard University

References & Publications (1)

Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E. Oxytocin increases trust in humans. Nature. 2005 Jun 2;435(7042):673-6. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Unethical behavior	To measure unethical behavior, we will calculate whether participants took more money than they actually earned on a problem-solving task.	130 minutes	No