Dyspnea Clinical Trial
Official title:
Effect of Muscle Reflex Inhibition on Cardiorespiratory Responses to Exercise in Hypoxia
The goal of this interventional study is to compare muscle reflex function under settings of normoxia (normal oxygen level), acute hypoxia (brief oxygen-lack) and chronic hypoxia (long-duration exposure to oxygen-lack). The main question is: Does the muscle reflex adapt to chronic hypoxia? Young, healthy participants will complete light-to-high intensity cycling exercise with and without suppression of the muscle reflex. Suppression of the muscle reflex will be via spinal administration of the opioid Fentanyl. In the control condition, saline will be administered into the spinal space. Participants will complete control (saline) and experimental (Fentanyl) exercise conditions at sea-level (Kelowna, BC, Canada) breathing room air and whilst breathing a lower fraction of oxygen (acute hypoxia). Thereafter, participants will complete the exercise test after living at high altitude (White Mountain, CA, USA) for 2 weeks whilst breathing room air (chronic hypoxia) and breathing a higher fraction of oxygen (restored normoxia).
Status | Not yet recruiting |
Enrollment | 14 |
Est. completion date | June 2024 |
Est. primary completion date | December 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 19 Years to 40 Years |
Eligibility | Inclusion Criteria: - aged 19 - 40 years old - not taking medications (exception oral contraception) - no history of cardiovascular, respiratory or neurological disease - members of the high altitude expedition to White Mountain in 2023 Exclusion Criteria: - post-menopausal or pregnant - obese - current smokers - taking prescription medications that may affect responses to exercise All potential participants will be screened by a physician to identify co-morbidities |
Country | Name | City | State |
---|---|---|---|
Canada | University of British Columbia - Okanagan Campus | Kelowna | British Columbia |
Lead Sponsor | Collaborator |
---|---|
University of British Columbia |
Canada,
Amann M, Proctor LT, Sebranek JJ, Pegelow DF, Dempsey JA. Opioid-mediated muscle afferents inhibit central motor drive and limit peripheral muscle fatigue development in humans. J Physiol. 2009 Jan 15;587(1):271-83. doi: 10.1113/jphysiol.2008.163303. Epub — View Citation
Wan HY, Weavil JC, Thurston TS, Georgescu VP, Bledsoe AD, Jessop JE, Buys MJ, Richardson RS, Amann M. The muscle reflex and chemoreflex interaction: ventilatory implications for the exercising human. J Appl Physiol (1985). 2020 Oct 1;129(4):691-700. doi: — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Exercise performance | Time, in seconds, to complete 7 kilometers of cycling, i.e. a time-trial | The duration, i.e., however long it takes to complete the exercise; this is typically 7-14 minutes | |
Primary | Ventilation | Ventilation, in liters per minute. | Data collected during steady-state breathing in the last minute of exercise | |
Secondary | Mean arterial blood pressure (entire pressure wave) | Blood pressure, in millimeters of mercury | Data collected during steady-state breathing in the last minute of exercise |
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