Dyspnea Clinical Trial
Official title:
Breathlessness Perception in COPD: Relationship With Exacerbation Frequency
The perception of breathlessness varies significantly among COPD patients with similar
severity of airflow limitation; those with poorer perception report less exacerbations as
compared to those with frequent exacerbations.
Cross-sectional comparison of breathlessness perception in COPD patients with frequent
exacerbations or without frequent exacerbations.
To assess "Breathlessness Perception" the investigators will increase the ventilatory demand
of the patients by CO2-rebreathing method.
The perception of breathlessness varies between individuals. This is a well-established
concept in asthma, but mostly unexplored in COPD; the relationship between airflow
limitation (FEV1, % ref.) and breathlessness (mMRC) is weak.
The perception of breathlessness varies significantly among COPD patients with similar
severity of airflow limitation; those with poorer perception report less exacerbations as
compared to those with frequent exacerbations.
It is a cross-sectional comparison of breathlessness perception in COPD patients with
frequent exacerbations (≥2 or ≥1 with hospitalization in the previous year) or without
frequent exacerbations (0 or 1 without hospitalization in the previous year).
To assess "Breathlessness Perception" the investigators will increase the ventilatory demand
of the patients by CO2-rebreathing method. CO2 rebreathing test will be conducted to
evaluate the acute ventilatory response to CO2 inhalation used to estimate central
chemoreceptor responsiveness in patients with the obstructive pulmonary disease.
Simple descriptive statistics (unpaired T-test) and correlation analysis (bivariate and
multivariate) will be used to analyze results.
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Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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