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Basics in Acute Shortness of Breath EvaLuation (BASEL V) Study — BASEL V  

Dyspnea Clinical Trial

Official title:
Basics in Acute Shortness of Breath EvaLuation (BASEL V) Study

Clinical Trial Summary

To improve the diagnostic and prognostic utility of various biomarkers, detailed patient's history, physical examinations and technical devices in patients presenting with acute dyspnea.

Clinical Trial Description

Background: Acute heart failure is a common disease associated with high morbidity and mortality. Unfortunately, pathophysiology and optimal initial treatment are both ill defined. Working Hypothesis: - Improved understanding of the pathophysiology underlying heart failure might allow more cause-specific treatment to this syndrome. - More rapid diagnosis of acute heart failure may allow to more rapidly initiate the appropriate treatment. - Cardiac dysfunction especially in comorbid dyspneic patients is not adequately characterized and the spectrum of acute heart failure is more diverse than originally thought. Methods: This is a large multicenter center, observational study enrolling unselected, consecutive patients with acute dyspnea presenting to the Emergency Department. Patient history, physical examination and laboratory parameters will be systematically obtained. Echocardiographic examinations will be routinely performed. Follow-up will be done at specified intervals (3, 6 and 12 months) after the initial presentation and risk predictors will be analyzed in multivariable regression models. Expected Value of the Proposed Project: The data obtained during this project will help to further improve diagnostics and prognostics in patients with acute dyspnea and to better understand underlying pathology of cardiac dysfunction in this cohort. Significance: The study aims are up-to-date and deal with an important health care problem in society. Conclusions drawn will significantly change care of patients with acute heart failure probably leading to a significant reduction of rehospitalization, morbidity and mortality. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01831115
Study type Observational
Source University Hospital, Basel, Switzerland
Contact
Status Active, not recruiting
Phase
Start date April 2006
Completion date December 2022
View Details
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