Cervix Cancer Clinical Trial
Official title:
Involvement of Matrix Metalloproteinases and Association With the Expression of Human Papillomavirus in Dysplasias and Cancers of the Cervix
This study aims to compare the expression of matrix metalloproteinases and their tissue inhibitors between 4 groups of patients defined according to the severity of the cervical lesion.
Cervical cancer is the second most common cancer among European women under 45 years old. It
is secondary to cervical dysplasia induced by persistent human papillomavirus infection. The
involvement of matrix metalloproteinases in carcinogenesis of the cervix is real, but their
expressions vary according to the published series. An association between the expression of
MMPs and that of the human papillomavirus deserves to be explored, as this can have a
prognostic influence in the case of gradual expression demonstrated in the development of
(pre) cancerous lesions of the cervix.
This study aims to compare the expression of matrix metalloproteinases and their tissue
inhibitors between 4 groups of patients defined according to the severity of the cervical
lesion.
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