Weight Loss Clinical Trial
Official title:
Esophageal Cancer (10030139, 10066354) Screening With FISH in Esophageal Cytology
This clinical trial studies whether esophageal cytology plus fluorescence in situ hybridization (FISH) is equal to or better than esophago-gastro-duodenoscopy (EGD) or upper endoscopy for the early detection of esophageal cancer. Genes are the units of deoxyribonucleic acid (DNA) the chemical structure carrying genetic information that determine many human characteristics. Certain genes in cancer cells may determine how the tumor grows or spreads and how it may respond to different drugs. Part of this study is to test those genes in esophageal cells using FISH.
PRIMARY OBJECTIVES:
I. Determine if sponge cytology with FISH is a reliable screening tool for esophageal
dysplasia/cancer, and determine its sensitivity and specificity, compared to the gold
standard procedure (upper endoscopy).
SECONDARY OBJECTIVES:
I. Determine if the cytology screening with FISH biomarkers is more cost effective than
upper endoscopy for the screening of esophageal cancer and the surveillance of esophageal
metaplasia and dysplasia.
II. Determine the limitations and future needs to improve this technique.
OUTLINE:
Participants swallow the capsule (Oesotest from Actimed) and then wait 10 minutes before the
sponge is pulled out through the esophagus by gentle traction on the string. Cytology
samples from the sponge are harvested and analyzed by FISH. Participants then undergo
standard EGD or upper endoscopy.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04506996 -
Monday-Focused Tailored Rapid Interactive Mobile Messaging for Weight Management 2
|
N/A | |
| Active, not recruiting |
NCT04420936 -
Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care for Our Program
|
N/A | |
| Terminated |
NCT03316105 -
Effect of T6 Dermatome Electrical Stimulation on Gastroduodenal Motility in Healthy Volunteers
|
N/A | |
| Completed |
NCT03700736 -
The Healthy Moms Study: Comparison of a Post-Partum Weight Loss Intervention Delivered Via Facebook or In-Person Groups
|
N/A | |
| Active, not recruiting |
NCT04353726 -
Knowledge-based Dietary Weight Management.
|
N/A | |
| Completed |
NCT02948283 -
Metformin Hydrochloride and Ritonavir in Treating Patients With Relapsed or Refractory Multiple Myeloma or Chronic Lymphocytic Leukemia
|
Phase 1 | |
| Completed |
NCT03377244 -
Healthy Body Healthy Souls in the Marshallese Population
|
N/A | |
| Completed |
NCT02877004 -
LLLT for Reducing Waste Circumference and Weight
|
N/A | |
| Active, not recruiting |
NCT04327141 -
Low Sugar Protein Pacing, Intermittent Fasting Diet in Men and Women
|
N/A | |
| Completed |
NCT03929198 -
Translation of Pritikin Program to the Community
|
N/A | |
| Recruiting |
NCT05249465 -
Spark: Finding the Optimal Tracking Strategy for Weight Loss in a Digital Health Intervention
|
N/A | |
| Recruiting |
NCT05942326 -
Sleep Goal-focused Online Access to Lifestyle Support
|
N/A | |
| Completed |
NCT00535600 -
Effects of Bariatric Surgery on Insulin
|
||
| Not yet recruiting |
NCT03601273 -
Bariatric Embolization Trial for the Obese Nonsurgical
|
Phase 1 | |
| Active, not recruiting |
NCT04357119 -
Common Limb Length in One-anastomosis Gastric Bypass
|
N/A | |
| Completed |
NCT02948517 -
Time Restricted Feeding for Weight Loss and Cardio-protection
|
N/A | |
| Completed |
NCT03210207 -
Gastric Plication in Mexican Patients
|
N/A | |
| Completed |
NCT02945410 -
Effect of Caloric Restriction and Protein Intake on Metabolism and Anabolic Sensitivity
|
N/A | |
| Completed |
NCT03139760 -
POWERSforID: A Telehealth Weight Management System for Adults With Intellectual Disability
|
N/A | |
| Recruiting |
NCT02559479 -
A Study to Assess the Effect of a Normal vs. High Protein Diets in Carbohydrates Metabolism in Obese Subjects With Diabetes or Prediabetes
|
N/A |