Frailty Clinical Trial
Official title:
Elucidating Factors Contributing to Dysphagia in Frail Older Adults
The purpose of this research study is to figure out if there are physical factors such as cognition level, nutrition status, walking speed, and handgrip strength that are associated with the development of swallowing problems. Investigators want to better understand how swallowing problems develop in older adults with and without frailty. Identifying factors that contribute to swallowing problems, can develop therapies in the future to improve swallowing outcomes for older adults. This study will be done at the University of Wisconsin-Madison (UW-Madison). A total of about 69 people will participate in this study.
This study has 3 specific aims: Aim 1 will determine the presence and severity of dysphagia in a cohort of older adults based on clinical frailty phenotype; Aim 2 will examine the effects of frailty status on physiological measures of swallowing in older adults; and Aim 3 will characterize relationships among specific functional frailty domains and dysphagia status in older adults. This proposed research will provide a new understanding of the factors that underlie and contribute to dysphagia across clinical frailty phenotypes. Equipped with this knowledge, future treatment and management approaches can be developed to proactively identify dysphagia risk factors in pre-frail and frail individuals so dysphagia can be prevented or adequately addressed. This work is highly significant due to the large and increasing population of aging people who often suffer from debilitating swallowing impairments and may benefit from optimized treatments that can be developed using knowledge gained from this study. Per approved protocol amendment on 3/39/2022, saliva samples will be collected to explore the composition and structure of oral microbiota via 16S rRNA gene analysis. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04992286 -
Detection, Evaluation and Monitoring of Frailties in the Elderly (FRAGING)
|
N/A | |
| Enrolling by invitation |
NCT05009706 -
Self-care in Older Frail Persons With Heart Failure Intervention
|
N/A | |
| Recruiting |
NCT05529147 -
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
|
||
| Recruiting |
NCT04444544 -
Quality of Life and High-Risk Abdominal Cancer Surgery
|
||
| Completed |
NCT04140890 -
Supporting Habit Formation to Attenuate Prefrailty in Elders: Pilot Study
|
N/A | |
| Completed |
NCT04061785 -
Impact of Skills Acquired Through Judo Training on Risk Factors for Falling in Elderly Men and Women
|
N/A | |
| Recruiting |
NCT03141866 -
Seated Physical Activity in Ageing
|
N/A | |
| Completed |
NCT04888884 -
Loss of Independence - a Rapid Alternative to Frailty Screening in a Swedish ED Setting
|
||
| Recruiting |
NCT04145726 -
Frailty In Thoracic Surgery for Esophageal Cancer
|
||
| Recruiting |
NCT04717869 -
Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty
|
||
| Not yet recruiting |
NCT06022666 -
PATH Program for for Severely Frail or Cognitively Impaired Patients Scheduled for Cancer Surgery.
|
N/A | |
| Not yet recruiting |
NCT06042244 -
Multimodal Exercise Training to Reduce Frailty in People With Multiple Sclerosis
|
N/A | |
| Not yet recruiting |
NCT04514536 -
Evaluation of a Health Monitoring Platform for Elderly in Home Care Context
|
N/A | |
| Completed |
NCT01126723 -
Effects of Tai Chi on Frailty in Elderly Adults
|
N/A | |
| Completed |
NCT00183040 -
HORMA: Hormonal Regulators of Muscle and Metabolism in Aging
|
Phase 2 | |
| Active, not recruiting |
NCT05961319 -
Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults
|
||
| Enrolling by invitation |
NCT05047731 -
Antihypertensive Deprescribing in Long-term Care
|
N/A | |
| Completed |
NCT04956705 -
Vitamin D and Calcium Supplementation at Danish Nursing Homes
|
N/A | |
| Recruiting |
NCT03824106 -
Frailty Rehabilitation
|
Phase 4 | |
| Recruiting |
NCT04518423 -
Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People
|