Dysphagia Clinical Trial
Official title:
Measuring the Effects of a Music Therapy Protocol on Respiratory and Bulbar Functions of Patients With Early and Mid-stage Amyotrophic Lateral Sclerosis: Mixed Methods Single Case Study Series
Verified date | July 2018 |
Source | Anglia Ruskin University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study evaluates potential of music therapy treatment to support breathing, speech, swallow and cough of persons with amyotrophic lateral sclerosis (ALS). Music therapy is the clinical use of music and its elements to enhance human health and wellbeing. Application of music therapy principles in neurorehabilitation allow to treat cognitive, sensory, and motor dysfunctions.
Status | Active, not recruiting |
Enrollment | 8 |
Est. completion date | January 1, 2020 |
Est. primary completion date | July 31, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Newly diagnosed patients at ALS Centre Moscow (consecutive sampling) - Diagnosis of probable or definite ALS by the revised El Escorial criteria confirmed by neurologist at ALS Moscow Centre prior to screening for enrollment. - Amyotrophic Lateral Sclerosis Functional Rating Scale - Revised (ALSFRS-R) bulbar subscore = 9, but = 11, where bulbar score=the sum of ALSFRS-R questions 1-3 (maximum score of 12) - Forced vital capacity (FVC) greater than 60% - Unimpaired cognition as evidenced by Edinburgh Cognitive and Behavioural ALS Screen (ECAS) cut-off scores adjusted for age and education - Able to consent to treatment - Native speakers of Russian Exclusion Criteria: - Tracheostomy or mechanical ventilation - Diaphragmatic pacer - Significant concurrent respiratory disease - Allergies to barium - Receiving any other experimental treatment for dysarthria, dysphagia, dystussia and dyspnoea for the duration of the study - Receiving any other music therapy treatment for the duration of the study |
Country | Name | City | State |
---|---|---|---|
Russian Federation | ALS Moscow Centre | Moscow | |
United Kingdom | Cambridge Institute for Music Therapy Research (CIMTR) | Cambridge | Cambridgeshire |
Lead Sponsor | Collaborator |
---|---|
Alisa Apreleva | ALS Centre Moscow |
Russian Federation, United Kingdom,
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* Note: There are 80 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change of Forced Vital Capacity (FVC) from baseline at Week 6, Week 12, Week 16 | FVC is a standard spirometry test which measures the volume of air that can forcibly be blown out after full inspiration. | Throughout the field phase of the study (16 weeks) | |
Primary | Change of Maximal Inspiratory Pressure (MIP) from baseline at Week 6, Week 12, Week 16 | MIP is the inspiratory pressure generated against a completely occluded airway; used to evaluate inspiratory respiratory muscle strength. | Throughout the field phase of the study (16 weeks) | |
Primary | Change of Maximal Expiratory Pressure (MEP) from baseline at Week 6, Week 12, Week 16 | MIP is a measure of the strength of respiratory muscles, obtained by having the patient exhale as strongly as possible against a mouthpiece. | Throughout the field phase of the study (16 weeks) | |
Primary | Change of Peak Cough Flow (PCF) from baseline at Week 6, Week 12, Week 16 | PCF is a measure of cough effectiveness, portable peak flow meter was used. | Throughout the field phase of the study (16 weeks) | |
Primary | Change of Center for Neurologic Study Bulbar Function Scale (CNS-BFS) Swallowing subscore from baseline at Week 6, Week 12, Week 16 | The Center for Neurologic Study Bulbar Function Scale (CNS-BFS) consists of three domains (swallowing, speech, and salivation), each of which is assessed with a 7-item, self report questionnaire. Each question is scored from "1" (does not apply) to "5" (applies most of the time). Swallowing domain subscore can range from "7" (best outcome) to "35" (worst outcome). | Throughout the field phase of the study (16 weeks) | |
Primary | Change of Center for Neurologic Study Bulbar Function Scale (CNS-BFS) Speech subscore from baseline at Week 6, Week 12, Week 16 | The Center for Neurologic Study Bulbar Function Scale (CNS-BFS) consists of three domains (swallowing, speech, and salivation), each of which is assessed with a 7-item, self report questionnaire. Each question is scored from "1" (does not apply) to "5" (applies most of the time). Speech domain subscore can range from "7" (best outcome) to "35" (worst outcome). | Throughout the field phase of the study (16 weeks) | |
Primary | Change in video fluoroscopic swallowing study (VFSS) results from baseline at Week 6, Week 12 | VFSS is an x-ray-based method of evaluating a person's swallowing ability. | Throughout the field phase of the study (16 weeks) | |
Primary | Change in acoustic assessment parameters of recorded voice from baseline at Week 6, Week 12, Week 16 | Machine-analyzed set of structured voice samples. | Throughout the field phase of the study (16 weeks) | |
Primary | Change in Visual Analogue Scale for current perceived ease of respiration from pre-treatment to post-treatment | Visual Analogue Scale (VAS) for current perceived ease of respiration is a one question 10-point scale administered at the beginning and at the end of every music therapy session to assess short-term change in current perceived ease of respiration. The outcome can range from "1" (very difficult) to "10" (very easy). | Throughout the therapy phase (6 weeks) | |
Primary | Change of Visual Analogue Scale for current perceived ease of speech from pre-treatment to post-treatment | Visual Analogue Scale (VAS) for current perceived ease of speech is a one question 10-point scale administered at the beginning and at the end of every music therapy session to assess short-term change in current perceived ease of speech. The outcome can range from "1" (very difficult) to "10" (very easy). | Throughout the therapy phase (6 weeks) | |
Primary | Phenomenological analysis of participant semi-structured interviews pre-treatment | Analysis of participant's answers to open questions in regards to expectations for music therapy treatment | Week 5 | |
Primary | Phenomenological analysis of caregiver semi-structured interview pre-treatment | Analysis of main caregiver's answers to open questions in regards to expectations for music therapy treatment | Week 5 | |
Primary | Phenomenological analysis of treatment sessions documentation | Analysis of narrative accounts of music therapy sessions submitted by the therapist | Throughout the therapy phase (6 weeks) | |
Primary | Phenomenological analysis of participant semi-structured interviews post-treatment | Analysis of participant's answers to open questions in regards to impressions of music therapy treatment | Week 13 | |
Primary | Phenomenological analysis of caregiver semi-structured interview post-treatment | Analysis of main caregiver's answers to open questions in regards to impressions of music therapy treatment | Week 13 |
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